Recombinant Full Length Human QDPR, His-tagged

• Cat.No.: QDPR-3613H
• Product Overview: Recombinant human QDPR protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-244 a.a.
• Description: QDPR is a member of the short-chain dehydrogenases/reductase(SDR) family of enzymes. Functioning as a homodimer, QDPR plays an important role in the recycling of tetrahydrobiopterin (BH4), an essential cofactor for the hydroxylation of the aromatic amino acids (tryptophan, tyrosine and phenylalanine). More specifically, QDPR catalyzes the regeneration of BH4 from quinonoid dihydrobiopterin (qBH2), the product generated from the hydroxylation reactions. Mutations in the gene encoding QDPR can lead to phenylketonuria II.
• Form: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 2mM DTT.
• Molecular Weight: 28.2 kDa (267aa), confirmed by MALDI-TOF
• Purity: > 90 % by SDS - PAGE
• Concentration: 1 mg/ml (determined by Bradford assay)
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MGSMAAAAAA GEARRVLVYG GRGALGSRCV QAFRARNWWV ASVDVVENEE ASASIIVKMT DSFTEQADQV TAEVGKLLGE EKVDAILCVA GGWAGGNAKS KSLFKNCDLM WKQSIWTSTI SSHLATKHLK EGGLLTLAGA KAALDGTPGM IGYGMAKGAV HQLCQSLAGK NSGMPPGAAA IAVLPVTLDT PMNRKSMPEA DFSSWTPLEF LVETFHDWIT GKNRPSSGSL IQVVTTEGRT ELTPAYF
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: QDPR quinoid dihydropteridine reductase [ Homo sapiens ]http://www.ncbi.nlm.nih.gov/sites/entrez
• Official Symbol: QDPR
• Synonyms: QDPR; DHPR; PKU2; SDR33C1; FLJ42391; quinoid dihydropteridine reductase; dihydropteridine reductase; HDHPR;EC 1.5.1.34; OTTHUMP00000158671; OTTHUMP00000217799; OTTHUMP00000217800; OTTHUMP00000217802; OTTHUMP00000217914; OTTHUMP00000217915; 6,7-dihydropteridine reductase; short chain dehydrogenase/reductase family 33C, member 1
• Gene ID: 5860
• mRNA Refseq: NM_000320
• Protein Refseq: NP_000311
• MIM: 612676
• UniProt ID: P09417
• Chromosome Location: 4p15.31
• Function: 6,7-dihydropteridine reductase activity; binding; electron carrier activity; oxidoreductase activity