QDPR
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Official Full Name
quinoid dihydropteridine reductase -
Overview
This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin.This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations.Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. -
Synonyms
QDPR;quinoid dihydropteridine reductase;dihydropteridine reductase;6;7 dihydropteridine reductase;DHPR;PKU2;SDR33C1;short chain dehydrogenase/reductase family 33C;member 1;DHPR_HUMAN;HDHPR;HPR;OTTHUMP00000158671;OTTHUMP00000217799;OTTHUMP00000217800;OTTHUMP00000217802;OTTHUMP00000217914;OTTHUMP00000217915;6,7-dihydropteridine reductase;short chain dehydrogenase/reductase family 33C, member 1
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cells
- HEK293
- His
- GST
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
QDPR involved in several pathways and played different roles in them. We selected most pathways QDPR participated on our site, such as Folate biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with QDPR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | UQCRC1,H2-KE6,ACSM4,COX7C,CMBL,ENO1,ENO2,POLR2A,DHCR24,PGAM2 |
| Folate biosynthesis | QDPRB2,GCH1,QDPRA,DHFR,ALPL,ALPI.1,MOCS1,ALP3,FPGS,SPR |
Protein Function
QDPR has several biochemical functions, for example, 6,7-dihydropteridine reductase activity,NADH binding,NADPH binding. Some of the functions are cooperated with other proteins, some of the functions could acted by QDPR itself. We selected most functions QDPR had, and list some proteins which have the same functions with QDPR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NADPH binding | CRYZ,DECR1,FASN,CBR4,CBR3,TP53I3,HMGCR,MTRR,KCNAB1,DHFR |
| protein homodimerization activity | ABCD2,HPGD,EIF2AK1,SYNE1,HOMER2,FGFR2,S100B,TCF3,GOT2,XCL1 |
| electron carrier activity | ACOX3,ACAD8,DHDH,ACOXL,GRXCR1,DHRS3,AOC2,NCF2,NDUFS6,CIAPIN1 |
| NADH binding | CTBP2A,CTBP1,CTBP2 |
Interacting Protein
QDPR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with QDPR here. Most of them are supplied by our site. Hope this information will be useful for your research of QDPR.
KRAS;CASP8;sch51344;APOA1;IQCB1
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