Recombinant Full Length Human Protein Kinase C, Gamma, GST-tagged, Active

• Cat.No.: PRKCG-404H
• Product Overview: Recombinant human full-length PKCgamma was expressed by baculovirus inSf9 cellsusing an N-terminal GST tag. MW=105 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• ProteinLength: 1-697 a.a.
• Description: PKCγ is a member of the protein kinase C (PKC) family of serine- and threonine-specific protein kinases that can phosphorylate a wide variety of protein targets known to be involved in diverse cellular signaling pathways. In the brain, PKCγ is translocated to cell membranes during ischemia and is rapidly removed or degraded during the second otherwise lethal ischemic insult in preconditioned brains. This suggest that ischemic preconditioning enhances downregulation of cell signaling mediated by PKCγ and may thereby provide neuroprotection.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: PRKCG protein kinase C, gamma [ Homo sapiens ]
• Synonyms: PRKCG; protein kinase C, gamma; PKCG; SCA14; MGC57564; PKC-gamma; Protein kinase C gamma type; EC 2.7.11.13
• Gene ID: 5582
• mRNA Refseq: NM_002739
• Protein Refseq: NP_002730
• UniProt ID: P05129
• Chromosome Location: 19q13.4
• MIM: 176980
• Pathway: Calcium signaling pathway; ErbB signaling pathway; Fc gamma R-mediated phagocytosis; Focal adhesion; Gap junction; Glioma; Leukocyte transendothelial migration; Long-term depression; Long-term potentiation; MAPK signaling pathway; Melanogenesis; Natural killer cell mediated cytotoxicity; Non-small cell lung cancer; Non-small cell lung cancer; Phosphatidylinositol signaling system; Tight junction; Vascular smooth muscle contraction; Vibrio cholerae infection; Wnt signaling pathway; Synaptic Transmission; Hemostasis
• Function: ATP binding; calcium ion binding; nucleotide binding; protein kinase C activity; transferase activity; zinc ion binding