Recombinant Full length Human Protein Kinase C, Delta, GST-tagged, Active

• Cat.No.: PRKCD-401H
• Product Overview: Recombinant human full-length PKCdelta was expressed by baculovirus inSf9 cellsusing an N-terminal GST tag. MW=104 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 1-676 a.a.
• Description: Protein kinase C delta (PKCδ) is a member of the protein kinase C (PKC) family of serine-threonine kinases. It is a 79 kd protein kinase that shows strict dependence on the presence of phospholipids, but shows no activation by Ca2+. Phosphatidylinositol is the most potent activator of PKC delta. Northern blot analysis indicated that PKCdelta is widely distributed in almost all the tissues and is a major isoform of PKC expressed in hemopoietic cells. PKCdelta is involved in fundamental cellular functions regulated by diacylglycerols and mimicked by phorbol esters.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Bio-activity: 350nmol/min/mg

Gene Information

• Gene Name: PRKCD protein kinase C, delta [ Homo sapiens ]
• Synonyms: PRKCD; protein kinase C, delta; MAY1; PKCD; MGC49908; nPKC-delta; Protein kinase C delta type; EC 2.7.11.13; protein kinase C delta VIII
• Gene ID: 5580
• mRNA Refseq: NM_006254
• Protein Refseq: NP_006245
• UniProt ID: Q05655
• Chromosome Location: 3p21.31
• MIM: 176977
• Pathway: Chemokine signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; GnRH signaling pathway; Neurotrophin signaling pathway; Tight junction; Type II diabetes mellitus; Vascular smooth muscle contraction; Apoptosis; Signalling by NGF
• Function: ATP binding; calcium-independent protein kinase C activity; enzyme activator activity; enzyme binding; insulin receptor substrate binding; metal ion binding; nucleotide binding; protein C-terminus binding; transferase activity; zinc ion binding