PRKCD

What is PRKCD protein?

PRKCD (protein kinase C delta) gene is a protein coding gene which situated on the short arm of chromosome 3 at locus 3p21. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. PRKCD protein is activated by diacylglycerol and is both a tumor suppressor and a positive regulator of cell cycle progression. Also, this protein can positively or negatively regulate apoptosis. This protein is consisted of 676 amino acids and is approximately 77.5 kDa.

What is the Function of PRKCD protein?

PRKCD is an important signal regulatory protein, which is involved in the regulation of many cell physiological processes, including apoptosis, cell proliferation and differentiation, inflammatory response and immune response. For example, PRKCD protein can phosphorylate multiple inflammation-related proteins, such as NF-κB, MAPK, etc., and thus participate in the process of inflammation.

PRKCD Related Signaling Pathway

PRKCD can activate several different mitogen-activated protein kinases (MAPKs), such as ERK1/2, p38 and JNK, which are involved in physiological processes such as cell proliferation, differentiation and apoptosis. It can also affect cell growth, differentiation and apoptosis by activating Janus kinase (JAK) and signal transduction and transcriptional activator (STAT) proteins. Or activate nuclear factor κB (NF-κB) through activation of IKK complex and degradation of IκB protein, thereby promoting inflammatory and immune responses.

NF-κB Signaling Pathway from TOCRIS.

PRKCD Related Diseases

PRKCD gene mutations may lead to the development of immune deficiency diseases, such as Wiskott-Aldrich syndrome, and may also lead to the development of autoimmune diseases, such as systemic lupus erythematosus and autoimmune lymphoproliferative syndrome 3 (ALPS3).

Bioapplications of PRKCD

PRKCD protein has a promising application in many disease fields, such as tumor and neurodegenerative diseases, and has the potential to become a new target for drug development and therapeutic strategies.

Case Study 1: HONGYUAN LIANG, 2023

Fig1. Colony formation assay in A549 and NCI-H292 cell lines: This experiment compared the cell colony-forming abilities among three groups: si-NC, si-1 PRKCD, and si-2 PRKCD.

Case Study 2: Xiangyu Li, 2022

Fig2. Measurement of protein expression levels of PRKCD in HepG2 and MHCC97H cells transfected with two PRKCD siRNA sequences, si-NC was utilized as the negative control.

PRKCD has several biochemical functions, for example, ATP binding,calcium-independent protein kinase C activity,enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKCD itself. We selected most functions PRKCD had, and list some proteins which have the same functions with PRKCD. You can find most of the proteins on our site.

PRKCD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKCD here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKCD.

N/A;FYN;IL32;TOP2A