Recombinant Full Length Human PGF Protein, C-His-tagged

Specification
Gene Information
Related Products
Download

Description :	PIGF-2, as know as placenta growth factor, is a member of the VEGF sub-family that a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. It is ultimately associated with angiogenesis. Specifically, it plays a role in trophoblast growth and differentiation. Also it is a potential biomarker for preeclampsia, a condition in which blood vessels in the placenta are too narrow, resulting in high blood pressure. Under normal physiologic conditions, it is also expressed at a low level in other organs including the heart, lung, thyroid, and skeletal muscle. Recombinant human PIGF-2, fused to His-tag at C-terminus, was expressed in HEK293 and purified by using conventional chromatography techniques.
Source :	HEK293T
Species :	Human
Tag :	His
Protein length :	19-170 aa
Form :	Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol.
Bio-activity :	Measured by its binding ability in a functional ELISA with Human VEGFR1/Flt-1.
Molecular Mass :	18.1kDa
AA Sequence :	LPAVPPQQWA LSAGNGSSEV EVVPFQEVWG RSYCRALERL VDVVSEYPSE VEHMFSPSCV SLLRCTGCCG DENLHCVPVE TANVTMQLLK IRSGDRPSYV ELTFSQHVRC ECRPLREKMK PERRRPKGRG KRRREKQRPT DCHLCGDAVP RR
Endotoxin :	< 1 EU per 1ug of protein (determined by LAL method).
Purity :	> 90% by SDS - PAGE.
Applications :	SDS-PAGE, Bioactivity
Notes :	For research use only. This product is not intended or approved for human, diagnostics or veterinary use.
Storage :	Can be stored at 2 centigrade to 8 centigrade for 1 week. For long term storage, aliquot and store at -20 centigrade to -80 centigrade. Avoid repeated freezing and thawing cycles.
Concentration :	0.5mg/ml (determined by Absorbance at 280nm).
References :	Asma Khalil., et al, (2008) PLoS One. 3:e2766. Khurana R., et al, (2005) Circulation. 111:2828-2836.

Gene Name	PGF placental growth factor [ Homo sapiens (human) ]
Official Symbol	PGF
Synonyms	PGF; placental growth factor; placenta growth factor isoform 1; D12S1900; PGFL; PIGF; PLGF; PlGF-2; SHGC-10760
Gene ID	5228
mRNA Refseq	NM_002632.6
Protein Refseq	NP_002623.2
MIM	601121
UniProt ID	P49763