Recombinant Full Length Human PDE4A Protein

• Cat.No.: PDE4A-366HF
• Product Overview: Recombinant full length Human PDE4A, isoform 4 with N terminal proprietary tag. Predicted MW 97.24 kDa.

Specification

• Description: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
• Source: In Vitro Cell Free System
• Species: Human
• Form: Liquid
• Molecular Mass: 97.240kDa inclusive of tags
• Protein length: 647 amino acids
• AA Sequence: MPLVDFFCETCSKPWLVGWWDQFKRMLNRELTHLSEMSRS GNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPS QPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKT DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIF QERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAA DVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNC DIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTM VETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPL ELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVE KSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWY YSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE EISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQE SLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSR EEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGL PSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGG GSGGDPT
• Purity: Proprietary Purification
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles.

Gene Information

• Gene Name: PDE4A phosphodiesterase 4A, cAMP-specific [ Homo sapiens ]
• Official Symbol: PDE4A
• Synonyms: PDE4A; phosphodiesterase 4A, cAMP-specific; DPDE2, phosphodiesterase 4A, cAMP specific (dunce (Drosophila) homolog phosphodiesterase E2); cAMP-specific 3,5-cyclic phosphodiesterase 4A; phosphodiesterase E2 dunce homolog (Drosophila)
• Gene ID: 5141
• mRNA Refseq: NM_001111307
• Protein Refseq: NP_001104777
• MIM: 600126
• UniProt ID: P27815