Recombinant Full Length Human PARN Protein

• Cat.No.: PARN-358HF
• Product Overview: Recombinant full length Human PARN with an N terminal proprietary tag; Predicted MWt 96.4 kDa.

Specification

• Species: Human
• Source: In Vitro Cell Free System
• Protein Length: 639 amino acids
• Description: The protein encoded by this gene is a 3-exoribonuclease, with similarity to the RNase D family of 3-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Form: Liquid
• Molecular Mass: 96.400kDa inclusive of tags
• AA Sequence: MEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSV SALTNGFDTPEERYQKLKKHSMDFLLFQFGLCTFKYDYTD SKYITKSFNFYVFPKPFNRSSPDVKFVCQSSSIDFLASQG FDFNKVFRNGIPYLNQEEERQLREQYDEKRSQANGAGALS YVSPNTSKCPVTIPEDQKKFIDQVVEKIEDLLQSEENKNL DLEPCTGFQRKLIYQTLSWKYPKGIHVETLETEKKERYIV ISKVDEEERKRREQQKHAKEQEELNDAVGFSRVIHAIANS GKLVIGHNMLLDVMHTVHQFYCPLPADLSEFKEMTTCVFP RLLDTKLMASTQPFKDIINNTSLAELEKRLKETPFNPPKV ESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGSF LSPPKIHVSARSKLIEPFFNKLFLMRVMDIPYLNLEGPDL QPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTS AFVSLSQPEQVKIAVNTSKYAESYRIQTYAEYMGRKQEEK QIKRKWTEDSWKEADSKRLNPQCIPYTLQNHYYRNNSFTA PSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEP LSEGRKKAKKLKRMKKELSPAGSISKNSPATLFEVPDTW
• Purity: Proprietary Purification
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles.
• Storage Buffer: pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione.

Gene Information

• Gene Name: PARN poly(A)-specific ribonuclease [ Homo sapiens ]
• Official Symbol: PARN
• Synonyms: PARN; poly(A)-specific ribonuclease; poly(A) specific ribonuclease (deadenylation nuclease); poly(A)-specific ribonuclease PARN; DAN; deadenylation nuclease
• Gene ID: 5073
• mRNA Refseq: NM_001134477
• Protein Refseq: NP_001127949
• MIM: 604212
• UniProt ID: O95453