PARN
-
Official Full Name
poly(A)-specific ribonuclease -
Overview
The protein encoded by this gene is a 3-exoribonuclease, with similarity to the RNase D family of 3-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] -
Synonyms
PARN;poly(A)-specific ribonuclease;DAN;poly(A)-specific ribonuclease PARN;deadenylating nuclease;deadenylation nuclease;polyadenylate-specific ribonuclease;poly(A)-specific ribonuclease (deadenylation nuclease)
Recombinant Proteins
- Zebrafish
- Mouse
- Chicken
- Human
- Mammalian Cells
- Wheat Germ
- HEK293
- E.coli
- Yeast
- In Vitro Cell Free System
- His
- Non
- Avi
- Fc
- GST
- DDK
- Myc
- Flag
Involved Pathway
PARN involved in several pathways and played different roles in them. We selected most pathways PARN participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PARN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA degradation | EXOSC2,PABPC1,EXOSC5,DnaK,PABPC1A,ENO1,PFKMA,EXOSC6,PABPC3,PNPT1 |
Protein Function
PARN has several biochemical functions, for example, mRNA 3-UTR binding,metal ion binding,nuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PARN itself. We selected most functions PARN had, and list some proteins which have the same functions with PARN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | TNKS2,CRYAB,ZFYVE26,ITGAX,CADPS,PXDN,MGAT4B,DDX59,NR1H5,NAIP6 |
| mRNA 3-UTR binding | RIMS2,SERBP1,RNPS1,CPEB3,KHSRP,CIRBP,RNF20,CPEB1B,TUT1,CPEB1A |
| nuclease activity | RNASEKB,MRE11A,RNASEL4,ENDOG,GDPD4,CNOT6L,ASTE1,RNASEL2,EAR5,USB1 |
| protein binding | SGTA,MALL,PRAME,IGSF1,CAML,RBM10,TARBP2,RPL30,KIF14,MCM4 |
| poly(A)-specific ribonuclease activity | CNOT6L,PDE12,PAN2,CNOT8,CNOT6,TOE1,CNOT7 |
| nucleotide binding | HSP104,RAP1AA,Aatk,HTATSF1,SLKA,EIF4A1B,AKAP17A,BMPR1BB,PIP5K2,EWSR1B |
| poly(A) RNA binding | LTA4H,DDX6,RPSA,GAR1,LUZP4,MRPL40,MTIF2,CFAP20,ELAVL2,NOSIP |
| protein kinase binding | TRIB3,CDK5R1,CALM,CCNL1B,NSF,HCLS1,NEK9,TNNI3,ZFP36,MAP3K12 |
Interacting Protein
PARN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARN here. Most of them are supplied by our site. Hope this information will be useful for your research of PARN.
BARD1;NCBP1;CSTF2;PABPC1;MPHOSPH6;SPATC1L;ssrna_a
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