Recombinant Full Length Human MAP2K5 Protein

• Cat.No.: MAP2K5-295HF
• Product Overview: Recombinant full length Human MEK5 with N terminal proprietary tag; predicted MWt 75.02 kDa including the tag.

Specification

• Description: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
• Source: In Vitro Cell Free System
• Species: Human
• Form: Liquid
• Molecular Mass: 75.020kDa inclusive of tags
• Protein length: 448 amino acids
• AA Sequence: MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLL FRDVLDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKA MLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQ MNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLD ITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKIL HRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTN AYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQ KNQGSLMPLQLLQCIVDEDSPVLPVGESSEPFVHFITQCM RKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVCRALEE RRSQQGPP
• Purity: Proprietary Purification
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles.
• Storage Buffer: pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione.

Gene Information

• Gene Name: MAP2K5 mitogen-activated protein kinase kinase 5 [ Homo sapiens ]
• Official Symbol: MAP2K5
• Synonyms: MAP2K5; mitogen-activated protein kinase kinase 5; PRKMK5; dual specificity mitogen-activated protein kinase kinase 5; HsT17454; MAPKK5; MEK5
• Gene ID: 5607
• mRNA Refseq: NM_001206804
• Protein Refseq: NP_001193733
• MIM: 602520
• UniProt ID: Q13163