MAP2K5
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Official Full Name
MAP2K5 mitogen-activated protein kinase kinase 5 -
Overview
Mitogen-activated protein kinase kinase 5 (MKK5) belongs to the serine/threonine protein kinase family and the MAPK subfamily (MAP2K, MKK or MEKs). MKK5 specifically phosphorylates erk5/MAPK7 within the kinase activation loop pThr-E-pTyr motif. After activation erk5 phosphorylates MKK5 on multiple phosphoserine residues. The MKK5/erk5 pathway may play an important role in prostate and breast cancer. -
Synonyms
MAP2K5;mitogen-activated protein kinase kinase 5;PRKMK5;dual specificity mitogen-activated protein kinase kinase 5;HsT17454;MAPKK5;MEK5;MEK 5;MAPKK 5;MAPK/ERK kinase 5;MAP kinase kinase 5;MAP kinase kinase MEK5b
Recombinant Proteins
- Human
- Rat
- Chicken
- Zebrafish
- Cynomolgus
- Mouse
- Human
- Wheat Germ
- Mammalian Cells
- HEK293
- Insect Cells
- Sf21 Cells
- In Vitro Cell Free System
- His
- Non
- GST
- Avi
- Fc
Involved Pathway
MAP2K5 involved in several pathways and played different roles in them. We selected most pathways MAP2K5 participated on our site, such as MAPK signaling pathway,Gap junction,Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gap junction | PDGFA,MAP3K2,CDK1,GNAS,TUBA3A,PRKG1,PRKG2,CX43,TUBB1,TUBB6 |
| Oxytocin signaling pathway | PRKAG3,PIK3R1,MAPK3,NFATC2,RYR3,PLA2G4C,PLCB2,GNAI1,CALM1,ELK1 |
| MAPK signaling pathway | MAPK12B,TRAF2,CACNA1C,NTRK1,CACNA1SA,MAPK9,MAP4K4,ARRB2,TAOK1,RASGRP3 |
| Neurotrophin signaling pathway | NGFRAP1,MAPK13,PSEN1,RAP1B,CDC42,MAGED1,BAX,PIK3R5,PIK3R3,MAPK8 |
Protein Function
MAP2K5 has several biochemical functions, for example, ATP binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K5 itself. We selected most functions MAP2K5 had, and list some proteins which have the same functions with MAP2K5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | SGK1,MAT1A,TEK,GUCY2C,DDX39,ATP1A3B,CHD2,RPS6KA3B,CHD4,PIP4K2A |
| metal ion binding | STK25,ZBTB8A,ITGA2B,PPTC7A,PPP1CB,ZNF213,SOBP,HBA-X,FAHD2A,UBA2 |
| protein binding | TTC39B,FYB,BANK1,FOXM1,TNFSF13B,KIF3B,LCA5,CDK7,GP1BB,HMGB2 |
| protein tyrosine kinase activity | EPHB4A,INSRA,PTK6B,FGR,Fert2,NTRK3A,FGFR4,CSF1RA,SRC,FGFR1OP |
| protein serine/threonine kinase activity | PAK3,Aatk,AKT3,STK39,STK35L,RPS6KC1,PAK2,CHEK1,MAP2K1,DCKL1B |
| protein kinase activity | CDC42BPB,IGF1RA,ACVR1,SGK3,PDPK1B,SGK2A,MAP4K6,DCLK2,PDK2,PRKCI |
Interacting Protein
MAP2K5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K5.
MAP3K3;MAPK7;HSP90AB1;GSK3B;GRB2;SIRT3;ESRRA;XRCC6;RPL28;YWHAZ;ASRGL1;LNX2;MAP3K2;CDC42BPB
Resources
Research Area
Kinases and Phosphatases in Endothelial CellsApoptosis Intracellular Kinases
Intracellular Kinases in the Akt Pathway
ROS and Stress Resistance
Mitogen-Activated Protein Kinase Kinases (MEKs/MKKs)
EMT Induction
Related Services
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References
