Recombinant Full Length Human KRT19 Protein, His-tagged

• Cat.No.: KRT19-7239H
• Product Overview: Recombinant Full Length Human KRT19 Protein with His tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-400 aa
• Description: The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21.
• Tag: His
• Molecular Mass: 47 kDa
• AA Sequence: MGSSHHHHHHSSGLVPRGSHMGSMTSYSYRQSSATSSFGGLGGGSVRFGPGVAFRAPSIHGGSGGRGVSVSSARFVSSSSSGAYGGGYGGVLTASDGLLAGNEKLTMQNLNDRLASYLDKVRALEAANGELEVKIRDWYQKQGPGPSRDYSHYYTTIQDLRDKILGATIENSRIVLQIDNARLAADDFRTKFETEQALRMSVEADINGLRRVLDELTLARTDLEMQIEGLKEELAYLKKNHEEEISTLRGQVGGQVSVEVDSAPGTDLAKILSDMRSQYEVMAEQNRKDAEAWFTSRTEELNREVAGHTEQLQMSRSEVTDLRRTLQGLEIELQSQLSMKAALEDTLAETEARFGAQLAHIQALISGIEAQLGDVRADSERQNQEYQRLMDIKSRLEQEIATYRSLLEGQEDHYNNLSASKVL
• Purity: >90% by SDS-PAGE
• Storage: Store it under sterile conditions at -20 to -80 °C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 1mg/mL by BCA
• Storage Buffer: Sterile PBS, pH7.4
• Publications:
  Pancreatic cancer cells assemble a CXCL12-keratin 19 coating to resist immunotherapy (2020)
  Carcinomas assemble a filamentous CXCL12–keratin-19 coating that suppresses T cell–mediated immune attack (2022)

Gene Information

• Gene Name: KRT19 keratin 19 [ Homo sapiens (human) ]
• Official Symbol: KRT19
• Synonyms: KRT19; keratin 19; keratin, type I cytoskeletal 19; 40 kDa keratin intermediate filament; CK19; cytokeratin 19; K1CS; K19; keratin; type I cytoskeletal 19; type I; 40 kd; MGC15366; CK-19; keratin-19; cytokeratin-19; keratin, type I, 40-kd; 40-kDa keratin intermediate filament
• Gene ID: 3880
• mRNA Refseq: NM_002276
• Protein Refseq: NP_002267
• MIM: 148020
• UniProt ID: P08727