Recombinant Full Length Human HNRNPM Protein, GST-tagged

• Cat.No.: HNRNPM-728HF
• Product Overview: Recombinant full length Human HNRNPM(1 a.a. - 730 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ.

Specification

• Description: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants.
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 103.9 kDa
• Protein length: 730 amino acids
• AA Sequence: MAAGVEAAAE VAATEIKMEE ESGAPGVPSG NGAPGPKGEG ERPAQNEKRK EKNIKRGGNR FEPYANPTKR YRAFITNIPF DVKWQSLKDL VKEKVGEVTY VELLMDAEGK SRGCAVVEFK MEESMKKAAE VLNKHSLSGR PLKVKEDPDG EHARRAMQKV MATTGGMGMG PGGPGMITIP PSILNNPNIP NEIIHALQAG RLGSTVFVAN LDYKVGWKKL KEVFSMAGVV VRADILEDKD GKSRGIGTVT FEQSIEAVQA ISMFNGQLLF DRPMHVKMDE RALPKGDFFP PERPQQLPHG LGGIGMGLGP GGQPIDANHL NKGIGMGNIG PAGMGMEGIG FGINKMGGME GPFGGGMENM GRFGSGMNMG RINEILSNAL KRGEIIAKQG GGGGGGSVPG IERMGPGIDR LGGAGMERMG AGLGHGMDRV GSEIERMGLV MDRMGSVERM GSGIERMGPL GLDHMASSIE RMGQTMERIG SGVERMGAGM GFGLERMAAP IDRVGQTIER MGSGVERMGP AIERMGLSME RMVPAGMGAG LERMGPVMDR MATGLERMGA NNLERMGLER MGANSLERMG LERMGANSLE RMGPAMGPAL GAGIERMGLA MGGGGGASFD RAIEMERGNF GGSFAGSFGG AGGHAPGVAR KACQIFVRNL PFDFTWKMLK DKFNECGHVL YADIKMENGK SKGCGVVKFE SPEVAERACR MMNGMKLSGR EIDVRIDRNA
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: HNRNPM heterogeneous nuclear ribonucleoprotein M [ Homo sapiens ]
• Official Symbol: HNRNPM
• Synonyms: HNRNPM; heterogeneous nuclear ribonucleoprotein M; HNRPM, NAGR1; CEA receptor; CEAR; HNRNPM4; HNRPM4; HTGR1; hnRNA-binding protein M4; N-acetylglucosamine receptor 1; heterogenous nuclear ribonucleoprotein M4; HNRPM; NAGR1; hnRNP M; DKFZp547H118
• Gene ID: 4670
• mRNA Refseq: NM_005968
• Protein Refseq: NP_005959
• MIM: 160994
• UniProt ID: P52272

Reviews

04/24/2022

Excellent in biochemical assays.

10/29/2020

Satisfied, product as described.

03/11/2019

Great for scientific research.

Q&As

In which cellular compartments is HNRNPM predominantly located?

HNRNPM is primarily located in the nucleus but can shuttle between the nucleus and cytoplasm.

How does HNRNPM influence RNA splicing?

It binds to pre-mRNA, influencing splice site selection and alternative splicing.

What role does HNRNPM play in alternative splicing?

It regulates alternative splicing by binding to specific RNA sequences.

Are there known genetic mutations that impact HNRNPM function?

Mutations and altered expression of HNRNPM have been linked to various cancers.

What is the primary role of HNRNPM in cellular processes?

HNRNPM is involved in RNA processing, including splicing, transport, and stability.

What research methods are commonly used to study HNRNPM?

Common research methods include RNA immunoprecipitation, western blot, and functional assays.

How is HNRNPM implicated in cancer progression?

HNRNPM can promote cancer progression by altering splicing to produce oncogenic isoforms.