Recombinant Full Length Human HEXB Protein

• Cat.No.: HEXB-228HF
• Product Overview: Recombinant full length Human HEXB with N-terminal proprietary tag. Predicted MW 87.23kDa.

Specification

• Description: Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines.Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes.Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases.Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses.Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II).
• Source: In Vitro Cell Free System
• Species: Human
• Form: Liquid
• Molecular Mass: 87.230kDa inclusive of tags
• Protein length: 556 amino acids
• AA Sequence: MELCGLGLPRPPMLLALLLATLLAAMLALLTQVALVVQVA EAARAPSVSAKPGPALWPLPLSVKMTPNLLHLAPENFY ISHSPNSTAGPSCTLLEEAFRRYHGYIFGFYKWHHEPAEF QAKTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEP VAVLKANRVWGALRGLETFSQLVYQDSYGTFTINESTIID SPRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVL HWHIVDDQSFPYQSITFPELSNKGSYSLSHVYTPNDVRMV IEYARLRGIRVLPEFDTPGHTLSWGKGQKDLLTPCYSR QNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKCWESNPKIQDFMRQKGFGTDFKKLESFYIQK VLDIIATINKGSIVWQEVFDDKAKLAPGTIVEVWKDSA YPEELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKVEP LDFGGTQKQKQLFIGGEACLWGEYVDATNLTPRLWPRA SAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERGIAAQPL YAGYCNHENM
• Purity: Proprietary Purification
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles.
• Storage Buffer: pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione.

Gene Information

• Gene Name: HEXB hexosaminidase B (beta polypeptide) [ Homo sapiens ]
• Official Symbol: HEXB
• Synonyms: HEXB; hexosaminidase B (beta polypeptide); beta-hexosaminidase subunit beta
• Gene ID: 3074
• mRNA Refseq: NM_000521
• Protein Refseq: NP_000512
• MIM: 606873
• UniProt ID: P07686