Recombinant Full Length Human FGF23 Protein, C-His-tagged

Cat.No. : FGF23-299H
Product Overview : Recombinant Full Length Human FGF23 Protein, fused to His-tag at C-terminus, was expressed in HEK293T.
  • Specification
  • Gene Information
  • Related Products
  • Download
Species : Human
Source : HEK293
Tag : His
Protein Length : 1-251 aa
Description : FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC).
Form : Lyophilized. Contains PBS.
Bio-activity : Activates ERK and FRS2α phosphorylation in Klotho expressing cells.
Molecular Mass : ~30kDa (SDS-PAGE, full-length). FGF23 is cleaved between Arg179 and Ser180 (two bands of ~14kDa and ~16kDa).
Endotoxin : <0.01EU/μg purified protein (LAL test; Lonza).
Purity : ≥90% (SDS-PAGE)
Storage : Short Term Storage: 4 centigrade
Long Term Storage: -20 centigrade
Shipping : BLUE ICE
Handling Advice : After reconstitution, prepare aliquots and store at -20 centigrade.
Avoid freeze/thaw cycles.
Centrifuge lyophilized vial before opening and reconstitution.
PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability : Stable for at least 6 months after receipt when stored at -20 centigrade.
Working aliquots are stable for up to 3 months when stored at -20 centigrade.
Reconstitution : Reconstitute with 100μl sterile water.
References : 1. Maternally-derived antibody to fibroblast growth factor-23 reduced dietary phosphate requirements in growing chicks: E.A. Bobeck, et al.; BBRC 420, 666 (2012)
2. Antibody to fibroblast growth factor 23-peptide reduces excreta phosphorus of laying hens: Z. Ren, et al.; Poultry Science 96, 127 (2017).
Gene Name FGF23 fibroblast growth factor 23 [ Homo sapiens (human) ]
Official Symbol FGF23
Synonyms FGF23; fibroblast growth factor 23; Fibroblast Growth Factor 23; Tumor-derived Hypophosphatemia-inducing Factor; ADHR; FGFN; HYPF; HFTC2; HPDR2; PHPTC
Gene ID 8074
mRNA Refseq NM_020638.3
Protein Refseq NP_065689.1
MIM 605380
UniProt ID Q9GZV9

Not For Human Consumption!

Inquiry

  • Reviews
  • Q&As

Customer Reviews (0)

Write a review

Q&As (0)

Ask a question

Ask a Question for All FGF23 Products

Required fields are marked with *

My Review for All FGF23 Products

Required fields are marked with *

0

Inquiry Basket

cartIcon