Recombinant Full Length Human FGF23 Protein, C-His-tagged
Cat.No. : | FGF23-299H |
Product Overview : | Recombinant Full Length Human FGF23 Protein, fused to His-tag at C-terminus, was expressed in HEK293T. |
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Species : | Human |
Source : | HEK293 |
Tag : | His |
Protein Length : | 1-251 aa |
Description : | FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC). |
Form : | Lyophilized. Contains PBS. |
Bio-activity : | Activates ERK and FRS2α phosphorylation in Klotho expressing cells. |
Molecular Mass : | ~30kDa (SDS-PAGE, full-length). FGF23 is cleaved between Arg179 and Ser180 (two bands of ~14kDa and ~16kDa). |
Endotoxin : | <0.01EU/μg purified protein (LAL test; Lonza). |
Purity : | ≥90% (SDS-PAGE) |
Storage : | Short Term Storage: 4 centigrade Long Term Storage: -20 centigrade |
Shipping : | BLUE ICE |
Handling Advice : | After reconstitution, prepare aliquots and store at -20 centigrade. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions. |
Use/Stability : | Stable for at least 6 months after receipt when stored at -20 centigrade. Working aliquots are stable for up to 3 months when stored at -20 centigrade. |
Reconstitution : | Reconstitute with 100μl sterile water. |
References : | 1. Maternally-derived antibody to fibroblast growth factor-23 reduced dietary phosphate requirements in growing chicks: E.A. Bobeck, et al.; BBRC 420, 666 (2012) 2. Antibody to fibroblast growth factor 23-peptide reduces excreta phosphorus of laying hens: Z. Ren, et al.; Poultry Science 96, 127 (2017). |
Gene Name | FGF23 fibroblast growth factor 23 [ Homo sapiens (human) ] |
Official Symbol | FGF23 |
Synonyms | FGF23; fibroblast growth factor 23; Fibroblast Growth Factor 23; Tumor-derived Hypophosphatemia-inducing Factor; ADHR; FGFN; HYPF; HFTC2; HPDR2; PHPTC |
Gene ID | 8074 |
mRNA Refseq | NM_020638.3 |
Protein Refseq | NP_065689.1 |
MIM | 605380 |
UniProt ID | Q9GZV9 |
◆ Recombinant Proteins | ||
Fgf23-417M | Recombinant Mouse Fibroblast Growth Factor 23, Fc Chimera | +Inquiry |
FGF23-1013H | Recombinant Human FGF23 Protein (Y25-R179), Tag Free | +Inquiry |
FGF23-2333R | Recombinant Rat FGF23 Protein | +Inquiry |
Fgf23-2998M | Recombinant Mouse Fgf23 Protein, Myc/DDK-tagged | +Inquiry |
FGF23-3589H | Recombinant Human FGF23 Protein (Ser180-Ile251), N-His tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
FGF23-6241HCL | Recombinant Human FGF23 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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