Active Recombinant Mouse Fgf23

• Cat.No.: Fgf23-27M
• Product Overview: Recombinant murine FGF-23 is a 25.5 kDa globular protein containing 228 amino acid residues.

Specification

• Species: Mouse
• Source: E.coli
• Tag: Non
• Description: This gene encodes a member of the fibroblast growth factor family. The encoded protein regulates phosphate homeostasis and vitamin D metabolism. Mutation of the related gene in humans causes autosomal dominant hypophosphatemic rickets (ADHR). The secreted protein is further cleaved into N- and C-terminal chains, which results in loss of function.
• Bio-activity: Determined by its ability to stimulate the proliferation of murine NIH-3T3 cells. The expected ED50 for this effect is 0.3-0.5 μg/ml, in the presence of murine Klotho and heparin.
• Molecular Mass: 25.5 kDa
• AA Sequence: MYPDTSPLLG SNWGSLTHLY TATARTSYHL QIHRDGHVDG TPHQTIYSAL MITSEDAGSV VITGAMTRRF LCMDLHGNIF GSLHFSPENC KFRQWTLENG YDVYLSQKHH YLVSLGRAKR IFQPGTNPPP FSQFLARRNE VPLLHFYTVR PRRHTRSAED PPERDPLNVL KPRPRATPVP VSCSRELPSA EEGGPAASDP LGVLRRGRGD ARGGAGGADR CRPFPRFV
• Purity: Greater than 95% by SDS-PAGE gel and HPLC analyses.

Gene Information

• Gene Name: Fgf23 fibroblast growth factor 23 [ Mus musculus (house mouse) ]
• Official Symbol: Fgf23
• Synonyms: Fgf23; fibroblast growth factor 23; fibroblast growth factor 23; FGF-23
• Gene ID: 64654
• mRNA Refseq: NM_022657
• Protein Refseq: NP_073148
• UniProt ID: Q9EPC2
• Chromosome Location: 6 F3; 6
• Pathway: Activated point mutants of FGFR2; DAP12 interactions; Downstream signal transduction
• Function: fibroblast growth factor receptor binding; growth factor activity; protein binding