Recombinant Full Length Human FBXL2 Protein, C-Flag-tagged

• Cat.No.: FBXL2-961HFL
• Product Overview: Recombinant Full Length Human FBXL2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 46.9 kDa
• AA Sequence: MVFSNNDEGLINKKLPKELLLRIFS FLDIVTLCRCAQISKAWNILALDGS NWQRIDLFNFQTDVEGRVVE NISKRCGGFLRKLSLRGCIGVGDSS LKTFAQNCRNIEHLNLNGCTKITDS TCYSLSRFCSKLKHLDLTSC VSITNSSLKGISEGCRNLEYLNLSW CDQITKDGIEALVRGCRGLKALLLR GCTQLEDEALKHIQNYCHEL VSLNLQSCSRITDEGVVQICRGCHR LQALCLSGCSNLTDASLTALGLNCP RLQILEAARCSHLTDAGFTL LARNCHELEKMDLEECILITDSTLI QLSIHCPKLQALSLSHCELITDDGI LHLSNSTCGHERLRVLELDN CLLITDVALEHLENCRGLERLELYD CQQVTRAGIKRMRAQLPHVKVHAYF APVTPPTAVAGSGQRLCRCC
  VILTRTRPLEQKLISEEDLAANDIL DYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome

Gene Information

• Gene Name: FBXL2 F-box and leucine rich repeat protein 2 [ Homo sapiens (human) ]
• Official Symbol: FBXL2
• Synonyms: FBL2; FBL3
• Gene ID: 25827
• mRNA Refseq: NM_012157.5
• Protein Refseq: NP_036289.3
• MIM: 605652
• UniProt ID: Q9UKC9