Recombinant Full Length Human FANCA Protein, GST-tagged

• Cat.No.: FANCA-4662HF
• Product Overview: Human FANCA full-length ORF ( AAH08979, 1 a.a. - 297 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia. [provided by RefSeq, Jul 2008]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 58.41 kDa
• Protein length: 297 amino acids
• AA Sequence: MSDSWVPRSASGQDPGGRRRAWAELLAGRVKREKYNPERAQKLKESAVRLLRSHQDLNALLLEVEGPLCKKLSLSKVIDCDSSEAYANHSSSFIGSALQDQASRLGVPVGILSAGMVASSVGQICTAPAETSHPVLLTVEQRKKLSSLLEFARYLLAHSMFSRLSFCQELWKIQSSLLLEAVWHLHVQGIVSLQELLESHPDMHAVGSWLFRNLCCLCEQMEASCQHADVARAMLSDFVQMFVLRGFQKNSDLRRTVEPEKMPQVAVDVLQRMLIFALDALAAGVQEESSTHKIVRC
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: FANCA Fanconi anemia, complementation group A [ Homo sapiens ]
• Official Symbol: FANCA
• Synonyms: FANCA; Fanconi anemia, complementation group A; FACA, FANCH; Fanconi anemia group A protein; FA H; FAA; FAH; Fanconi anemia, type 1; Fanconi anemia, complementation group H; FA; FA1; FA-H; FACA; FANCH; MGC75158
• Gene ID: 2175
• mRNA Refseq: NM_000135
• Protein Refseq: NP_000126
• MIM: 607139
• UniProt ID: O15360