Recombinant Full Length Human DOLK Protein

• Cat.No.: DOLK-3947HF
• Product Overview: Human DOLK full-length ORF (ADZ15912.1) recombinant protein without tag.

Specification

• Description: The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency.[provided by RefSeq, Apr 2010]
• Source: In Vitro Cell Free System
• Species: Human
• Form: Liquid
• Molecular Mass: 59.2 kDa
• Protein length: 289 amino acids
• AA Sequence: MTRECPSPAPGPGAPLSGSVLAEAA VVFAVVLSIHATVWDRYSWCAVALA VQAFYVQYKWDRLLQQGSAVFQFRM SANSGLLPASMVMPLLGLVMKERCQ TAGNPFFERFGIVVAATGMAVALFS SVLALGITRPVPTNTCVILGLAGGV IIYIMKHSLSVGEVIEVLEVLLIFV YLNMILLYLLPRCFTPGEALLVLGG ISFVLNQLIKRSLTLVESQGDPVDF FLLVVVVGMVLMGIFFSTLFVFMDS GTWASSIFFHLMTCVLSLGVVLPWL HRLIRRNPLLWLLQFLFQTDTRIYL LAYWSLLATLACLVVLYQNAKRSSS ESKKHQAPTIARKYFHLIVVATYIP GIIFDRPLLYVAATVCLAVFIFLEY VRYFRIKPLGHTLRSFLSLFLDERD SGPLILTHIYLLLGMSLPIWLIPRP CTQKGSLGGARALVPYAGVLAVGVG DTVASIFGSTMGEIRWPGTKKTFEG TMTSIFAQIISVALILIFDSGVDLN YSYAWILGSISTVSLLEAYTTQIDN LLLPLYLLILLMA
• Applications: Antibody Production
  Functional Study
  Compound Screening
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 25 mM Tris-HCl of pH 8.0 containing 2% glycerol.

Gene Information

• Gene Name: DOLK dolichol kinase [ Homo sapiens ]
• Official Symbol: DOLK
• Synonyms: DOLK; dolichol kinase; TMEM15, transmembrane protein 15; DK1; dolichol kinase 1; KIAA1094; SEC59 homolog; transmembrane protein 15; DK; CDG1M; SEC59; TMEM15
• Gene ID: 22845
• mRNA Refseq: NM_014908
• Protein Refseq: NP_055723
• MIM: 610746
• UniProt ID: Q9UPQ8