Recombinant Full Length Human CYP2B6 Protein

• Cat.No.: CYP2B6-108HF
• Product Overview: Recombinant full length Human Cytochrome P450 2B6 with an N terminal proprietary tag; Predicted MWt 80.08 kDa.

Specification

• Species: Human
• Source: In Vitro Cell Free System
• Protein Length: 491 amino acids
• Description: This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.
• Form: Liquid
• Molecular Mass: 80.080kDa inclusive of tags
• AA Sequence: MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLL GNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCG VEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKS KGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLN LFYQTFSLISSVFGQLFELFSGFLTYFPGAHRQVYKNLQE INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEEEKSNAH SEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHV AERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPH YFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEG IARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI PPTYQIRFLPR
• Purity: Proprietary Purification
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles.
• Storage Buffer: pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione.

Gene Information

• Gene Name: CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 [ Homo sapiens ]
• Official Symbol: CYP2B6
• Synonyms: CYP2B6; cytochrome P450, family 2, subfamily B, polypeptide 6; CYP2B, cytochrome P450, family 2, subfamily B , cytochrome P450, subfamily IIB (phenobarbital inducible) , cytochrome P450, subfamily IIB (phenobarbital inducible), polypeptide 6; cytochrom
• Gene ID: 1555
• mRNA Refseq: NM_000767
• Protein Refseq: NP_000758
• MIM: 123930
• UniProt ID: P20813