CYP2B6
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Official Full Name
cytochrome P450, family 2, subfamily B, polypeptide 6 -
Overview
This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. -
Synonyms
CYP2B6;cytochrome P450, family 2, subfamily B, polypeptide 6;CYP2B, cytochrome P450, family 2, subfamily B , cytochrome P450, subfamily IIB (phenobarbital inducible) , cytochrome P450, subfamily IIB (phenobarbital inducible), polypeptide 6;cytochrome P450 2B6;CPB6;CYPIIB6;11B1;CP2B6_HUMAN;CPB 6;CYP 2B6;CYP IIB6;CYP2B;CYP2B7;CYP2B7P;Cytochrome P450 family 2 subfamily B;Cytochrome P450 family 2 subfamily B polypeptide 6;Cytochrome P450 IIB1;Cytochrome P450 phenobarbital inducible;Cytochrome P450 subfamily IIB (phenobarbital inducible);Cytochrome P450 subfamily IIB (phenobarbital inducible) polypeptide 6;Cytochrome P450 subfamily IIB polypeptide 6;IIB1;P450;P450 IIB1;P450IIB1;cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6
Recombinant Proteins
- Rhesus macaque
- Human
- Cynomolgus
- Dog
- Mammalian Cell
- HEK293
- Wheat Germ
- Insect Cell
- In Vitro Cell Free System
- E.coli
- Mammalian cells
- HEK293T
- His
- Myc&DDK
- GST
- Non
- His&Fc&Avi
- Flag
Involved Pathway
CYP2B6 involved in several pathways and played different roles in them. We selected most pathways CYP2B6 participated on our site, such as Arachidonic acid metabolism,Biological oxidations,CYP2E1 reactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2B6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | CYP2U1,FAM213B,AGXTB,MGAT1B,NDUFS1,DPM1,CYP2R1,IPMK,RDH8B,CERS4 |
| Drug metabolism - cytochrome P450 | CYP2C8,ADH7,ADH5,ADH1C,GSTK1,ADH1B,CYP2C19,ADH4,CYP2C9,ADH6 |
| Cytochrome P450 - arranged by substrate type | CYP2V1,CYP2F1,CYP1A1,CYP2AD3,POMCB,CYP2A7,FAM84B,FDXR,CYP4T8,CYP2A6 |
| Fatty acids | CYP2AD3,CYP2A13,CYP2D6,CYP4F12,CYP2V1,CYP4A11,CYP2N13,CYP4F11,CYP2A7,CYP2J2 |
| Biological oxidations | GLYATL2,CYP2K17,CYP2K8,UGT1B7,CYP2A6,CYP26A1,CYP3C4,UGT1B1,ACY3,CYP2K6 |
| Metabolism | ITPKB,B3GNT2,CYP26A1,B3GAT2,ACAD11,MTF1,CYB5R3,CERS3B,CTH,GCKR |
| CYP2E1 reactions | CYP2E1,CYP2A13,CYP2Y3,CYP2A7,CYP2C9,CYP2C19,CYP2A6,CYP2D6,CYP2F1,CYP2S1 |
| Arachidonic acid metabolism | CYP1A2,GPX1,CYP2P10,PLA2G12B,CYP4F14,ALOX15,PLA2G4AA,CYP2B19,CYP1A1,GPX3 |
Protein Function
CYP2B6 has several biochemical functions, for example, arachidonic acid epoxygenase activity,heme binding,iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2B6 itself. We selected most functions CYP2B6 had, and list some proteins which have the same functions with CYP2B6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| monooxygenase activity | CYP4V2,CYP20A1,CYP3C4,CYP3A25,CYP19A1A,CYP46A1.2,CYP2Y3,CYP4A12A,FMO1,CYP4F18 |
| steroid hydroxylase activity | CYP2P10,CYP21A2,CYP2AD6,CYP2AA2,CYP2AA3,CYP2P6,CYP2C18,CYP2AA4,CYP46A1.2,CYP2V1 |
| arachidonic acid epoxygenase activity | CYP2C55,CYP2AA12,CYP2A6,CYP2C54,CYP2A7,CYP2C50,CYP2B19,CYP2C19,CYP2N13,CYP2A4 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP2C70,CYP2E1,CYP2C9,CYP2X9,CYP2AA9,CYP2X10.2,CYP2K19,CYP2A7,CYP2A12,CYP2P7 |
| iron ion binding | CYP4F2,TH2,CYP24A1,LEPRE1,ALOX5B.3,ALOX15B,Scd1,CYP2A12,CYP3A5,PPEF2 |
| oxygen binding | CYP2C8,CYP2C70,HBB-BH1,CYP2X9,HBZ,CYP2J6,CYP2D26,CYP2J2,CYP2AD2,CYP1B1 |
| heme binding | CYP2AD3,CYP4F14,CYP2AA6,CYP2K16,CYP46A1,CYP2C55,PTGIS,Adgb,PGRMC2,CYP4F22 |
Interacting Protein
CYP2B6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2B6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2B6.
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References
- Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
- Liu, ZH; Li, L; et al. Characterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In Vivo. DRUG METABOLISM AND DISPOSITION 43:208-216(2015).
