Recombinant Full Length Human CES1 Protein

• Cat.No.: CES1-71HF
• Product Overview: Recombinant full length Human Liver Carboxylesterase 1 with N terminal proprietary tag; Predicted MWt 87.67 kDa.

Specification

• Species: Human
• Source: In Vitro Cell Free System
• Protein Length: 567 amino acids
• Description: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.
• Form: Liquid
• Molecular Mass: 87.670kDa inclusive of tags
• AA Sequence: MWLPALVLATLAASAAWGHPSSPPVVDTVHGKVLGKFVSL EGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNA TSYPPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLN IYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAH ENVVVVTIQYRLGTWGFFSTGDEHSRGNWGHLDQVAALRW VQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLF HRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTSA VMVHCLRQKTEEELLETTLKMKFLSLDLQGDPRESQPLLG TVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIP MLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATE KYLGGTDDTVKKKDLFLDLIADVMFGVPSVIVARNHRDAG APTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPFL KEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYN QKEGYLQIGANTQAAQKLKDKEVAFWTNLFAKKAVEKPPQ TEHIEL
• Purity: Proprietary Purification
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles.
• Storage Buffer: pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione.

Gene Information

• Gene Name: CES1 carboxylesterase 1 [ Homo sapiens ]
• Official Symbol: CES1
• Synonyms: CES1; carboxylesterase 1; carboxylesterase 1 (monocyte/macrophage serine esterase 1); liver carboxylesterase 1; CEH; CES1A1; CES1A2; CES2; HMSE; HMSE1; human monocyte/macrophage serine esterase 1; SES1
• Gene ID: 1066
• mRNA Refseq: NM_001025194
• Protein Refseq: NP_001020365
• MIM: 114835
• UniProt ID: P23141