CES1
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Official Full Name
carboxylesterase 1 -
Overview
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] -
Synonyms
CES1;carboxylesterase 1;CEH;REH;TGH;ACAT;CE-1;CES2;HMSE;SES1;HMSE1;PCE-1;hCE-1;liver carboxylesterase 1;egasyn;serine esterase 1;retinyl ester hydrolase;cocaine carboxylesterase;triacylglycerol hydrolase;carboxylesterase 2 (liver);brain carboxylesterase hBr1;cholesteryl ester hydrolase;monocyte/macrophage serine esterase;methylumbelliferyl-acetate deacetylase 1;acyl coenzyme A:cholesterol acyltransferase;acyl-coenzyme A:cholesterol acyltransferase;human monocyte/macrophage serine esterase 1;carboxylesterase 1 (monocyte/macrophage serine esterase 1)
Recombinant Proteins
- Human
- Cynomolgus
- Mouse
- Insect Cells
- E.coli
- HEK293
- Wheat Germ
- Mammalian Cells
- NS0
- In Vitro Cell Free System
- Insect cells
- His
- GST
- Non
- Flag
- Avi&Fc&His
- DDK&Myc
- His&Myc
Involved Pathway
CES1 involved in several pathways and played different roles in them. We selected most pathways CES1 participated on our site, such as Biological oxidations,Drug metabolism - other enzymes,E2F transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with CES1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| E2F transcription factor network | CBX5,CES5A,HIC1,RBBP8,PRMT5,RYBP,E2F4,YY1,MYBL2,CEBPA |
| Biological oxidations | ADH8B,SULT4A1,CYP1A2,CYP27A1,CYP3A4,ADH6,ADH4,Sult2a2,AADAC,CYP2C19 |
| Metabolic pathways | UMPS,POLR3F,GBGT1L4,GNSA,PLCB4,PIP5K1BB,AGLA,POLG2,CHPF2,AK4 |
| Metabolism | SLC25A20,ADA,BSG,ZDHHC21,CLPS,DBH,PDP1,NUDT18,UCP3,DAO |
| Fluoropyrimidine Activity | UPP2,SLC22A7,DPYD,DPYS,DHFR,TYMP |
| Phase 1 - Functionalization of compounds | CYP2AD6,CYP2Y3,CYP4T8,CYP2V1,CYP2K18,CYP3C4,CYP2W1,CYP2U1,CYP2K17,CYP26A1 |
| Drug metabolism - other enzymes | UMPS,CES1D,IMPDH1A,UGT5G1,TK1,IMPDH1B,UPP1,UGT2A3,UGT1A9,UGT2B7 |
Protein Function
CES1 has several biochemical functions, for example, carboxylic ester hydrolase activity,methylumbelliferyl-acetate deacetylase activity,sterol esterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CES1 itself. We selected most functions CES1 had, and list some proteins which have the same functions with CES1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| methylumbelliferyl-acetate deacetylase activity | CES2,ESD |
| triglyceride lipase activity | PNLIPRP3,LIPE,LIPC,CES3,CES5A,PNPLA4,LIPCA,PNPLA3,PNLIPRP1,LIPF |
| carboxylic ester hydrolase activity | ACOT5,ESD,AADACL2,ACOT12,ACOT9,FAM135A,BAAT,CES1D,ACOT11,Ces2e |
| sterol esterase activity | CEL.1,Cel,LIPA,CES3,CES5A,CES1D |
Interacting Protein
CES1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CES1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CES1.
CREB3
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References
- Ishizuka, T; Yoshigae, Y; et al. Different Hydrolases Involved in Bioactivation of Prodrug-Type Angiotensin Receptor Blockers: Carboxymethylenebutenolidase and Carboxylesterase 1. DRUG METABOLISM AND DISPOSITION 41:1888-1895(2013).
- Zhao, B; Bie, JH; et al. Identification of a novel intracellular cholesteryl ester hydrolase (carboxylesterase 3) in human macrophages: compensatory increase in its expression after carboxylesterase 1 silencing. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 303:C427-C435(2012).
