Recombinant Full Length Human BCDIN3D Protein, GST-tagged

• Cat.No.: BCDIN3D-1611HF
• Product Overview: Human BCDIN3D full-length ORF ( NP_859059.1, 1 a.a. - 292 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes an RNA methyltransferase which belongs to the rossmann fold methyltransferase family, and serves as a 5'-methylphosphate capping enzyme that is specific for cytoplasmic histidyl tRNA. The encoded protein contains an S-adenosylmethionine binding domain and uses the methyl group donor, S-adenosylmethionine. This gene is overexpressed in breast cancer cells, and is related to the tumorigenic phenotype and poor prognosis of breast cancer. The encoded protein is thought to promote the cellular invasion of breast cancer cells, by downregulating the expression of tumor suppressor miRNAs through the dimethylation of the 5-monophosphate of the corresponding precursor miRNAs.
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 59.6 kDa
• Protein length: 292 amino acids
• AA Sequence: MAVPTELDGG SVKETAAEEE SRVLAPGAAP FGNFPHYSRF HPPEQRLRLL PPELLRQLFP ESPENGPILG LDVGCNSGDL SVALYKHFLS LPDGETCSDA SREFRLLCCD IDPVLVKRAE KECPFPDALT FITLDFMNQR TRKVLLSSFL SQFGRSVFDI GFCMSITMWI HLNHGDHGLW EFLAHLSSLC HYLLVEPQPW KCYRAAARRL RKLGLHDFDH FHSLAIRGDM PNQIVQILTQ DHGMELICCF GNTSWDRSLL LFRAKQTIET HPIPESLIEK GKEKNRLSFQ KQ
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: BCDIN3D BCDIN3 domain containing [ Homo sapiens ]
• Official Symbol: BCDIN3D
• Synonyms: BCDIN3 Domain Containing RNA Methyltransferase; RNA 5'-Monophosphate Methyltransferase; BCDIN3 Domain-Containing Protein; BCDIN3 Domain Containing RNA Methyltransfease; Pre-MiRNA 5'-Monophosphate Methyltransferase; Probable Methyltransferase BCDIN3D; BCDIN3 Domain Containing; EC 2.1.1
• Gene ID: 144233
• mRNA Refseq: NM_181708.2
• Protein Refseq: NP_859059.1
• MIM: 619601
• UniProt ID: Q7Z5W3