Recombinant Full Length Human ATP6V1H Protein, GST-tagged

• Cat.No.: ATP6V1H-1294HF
• Product Overview: Human ATP6V1H full-length ORF ( AAH25275, 1 a.a. - 483 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles. V-ATPase-dependent organelle acidification is necessary for multiple processes including protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. The encoded protein is the regulatory H subunit of the V1 domain of V-ATPase, which is required for catalysis of ATP but not the assembly of V-ATPase. Decreased expression of this gene may play a role in the development of type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 78.87 kDa
• Protein length: 483 amino acids
• AA Sequence: MTKMDIRGAV DAAVPTNIIA AKAAEVRANK VNWQSYLQGQ MISAEDCEFI QRFEMKRSPE EKQEMLQTEG SQCAKTFINL MTHICKEQTV QYILTMVDDM LQENHQRVSI FFDYARCSKN TAWPYFLPML NRQDPFTVHM AARIIAKLAA WGKELMEGSD LNYYFNWIKT QLSSQKLRGS GVAVETGTVS SSDSSQYVQC VAGCLQLMLR VNEYRFAWVE ADGVNCIMGV LSNKCGFQLQ YQMIFSIWLL AFSPQMCEHL RRYNIIPVLS DILQESVKEK VTRIILAAFR NFLEKSTERE TRQEYALAMI QCKVLKQLEN LEQQKYDDED ISEDIKFLLE KLGESVQDLS SFDEYSSELK SGRLEWSPVH KSEKFWRENA VRLNEKNYEL LKILTKLLEV SDDPQVLAVA AHDVGEYVRH YPRGKRVIEQ LGGKQLVMNH MHHEDQQVRY NALLAVQKLM VHNWEYLGKQ LQSEQPQTAA ARS
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H [ Homo sapiens ]
• Official Symbol: ATP6V1H
• Synonyms: ATP6V1H; ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H; ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H; V-type proton ATPase subunit H; CGI 11; SFD; SFDalpha; SFDbeta; vacuolar ATP synthase subunit H; VMA13; V-ATPase H subunit; V-ATPase subunit H; nef-binding protein 1; protein VMA13 homolog; vacuolar ATPase subunit H; V-ATPase 50/57 kDa subunits; vacuolar proton pump H subunit; vacuolar proton pump subunit H; vacuolar proton pump subunit SFD; NBP1; CGI-11; MSTP042
• Gene ID: 51606
• mRNA Refseq: NM_015941
• Protein Refseq: NP_057025
• MIM: 608861
• UniProt ID: Q9UI12