ATP6V1H

  • Official Full Name

    ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H

  • Overview

    This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the regulatory H subunit of the V1 domain which is required for catalysis of ATP but not the assembly of V-ATPase. Three alternatively spliced transcript variants encode two isoforms of the H subunit.

  • Synonyms

    ATP6V1H;ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H;ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H;V-type proton ATPase subunit H;CGI 11;SFD;SFDalpha;SFDbeta;vacuolar ATP synthase subunit H;VMA13;CGI11;EC 3.6.3.14;MSTP042;NBP1;Nef binding protein 1;Nef-binding protein 1;Protein VMA13 homolog;V ATPase subunit H;V-ATPase 50/57 kDa subunits;V-ATPase subunit H;Vacuolar proton pump subunit H;Vacuolar proton pump subunit SFD;VATH_HUMAN;OTTHUMP00000226227;OTTHUMP00000226228;OTTHUMP00000226253;OTTHUMP00000226254;V-ATPase H subunit;vacuolar ATPase subunit H;vacuolar proton pump H subunit;CGI-11

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • Zebrafish
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • In Vitro Cell Free System
  • HEK293T
  • GST
  • His
  • Non
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
ATP6V1H-1012H Recombinant Human ATP6V1H protein, GST-tagged Wheat Germ Human GST
ATP6V1H-2170M Recombinant Mouse ATP6V1H Protein Mammalian Cell Mouse His
ATP6V1H-4175C Recombinant Chicken ATP6V1H Mammalian Cell Chicken His
ATP6V1H-8445Z Recombinant Zebrafish ATP6V1H Mammalian Cell Zebrafish His
ATP6V1H-9541Z Recombinant Zebrafish ATP6V1H Mammalian Cell Zebrafish His
ATP6V1H-8573HCL Recombinant Human ATP6V1H 293 Cell Lysate HEK293 Human Non
ATP6V1H-1294HF Recombinant Full Length Human ATP6V1H Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 483 amino acids
ATP6V1H-2410H Recombinant Human ATP6V1H Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
Atp6v1h-376M Recombinant Mouse Atp6v1h Protein, MYC/DDK-tagged HEK293T Mouse Myc&DDK
ATP6V1H-884M Recombinant Mouse ATP6V1H Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
ATP6V1H-884M-B Recombinant Mouse ATP6V1H Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    ATP6V1H involved in several pathways and played different roles in them. We selected most pathways ATP6V1H participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V1H were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolic pathways CYP19A1,DOLK,CSGALNACT2,PDXKA,MECR,LPIN1,PON3,PRPS1,ADH1,GUK1A
    Vibrio cholerae infection ATP6V1E2,ATP6V0C,PLCG2,ATP6V0B,PLCG1,ERO1L,PRKCA,SEC61G,KDELR3,ATP6V0D2
    Phagosome MBL1,MHC2DEB,TUBA8L2,DYNC2H1,TUBB5,FCGR2A,CALR,FCGR1A,THBS3A,ACTB1
    Epithelial cell signaling in Helicobacter pylori infection ATP6V0C,MAPK13,PAK1,IL-8,ATP6V0D1,MAPK12,ATP6V0A1,RAC1,GIT1,ATP6V1C1
    Synaptic vesicle cycle ATP6V0C,ATP6V0E2,ATP6V1G2,ATP6V0A2,STX1B,ATP6V0D1,ATP6V0D2,DNM3,CPLX4,SYT1
    Oxidative phosphorylation COX7A2A,ATP6V1G3,NDUFA11,ATP6V1A,NDUFA6,SDHDB,ATP5D,NDUFS8A,SDHA,COX17
    Rheumatoid arthritis IL6,TLR4,TNFRSF11A,CD86,Ccl12,ATP6V1F,ATP6V0A2,MMP1,IL17A,TNFSF13
    Lysosome CLTCA,CTSL1B,CLN5,ATP6V0D1,CTSBA,AP3M2,ATP6V0A1,ATP6V0CA,IGF2R,ATP6AP1B
    Tuberculosis HLA-DMB,HLA-DQA1,EEA1,ITGB2,MAPK11,cgr2b,CASP8,APAF1,HSPD1,FCGR2B

    Protein Function

    ATP6V1H has several biochemical functions, for example, contributes_to ATPase activity,enzyme regulator activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V1H itself. We selected most functions ATP6V1H had, and list some proteins which have the same functions with ATP6V1H. You can find most of the proteins on our site.

    Function Related Protein
    enzyme regulator activity DCP1B,PSMD3,PSMD1,CPN2,APOC3,GCLM,RGN,BRCC3,RAB3GAP2,PSMD2
    proton-transporting ATPase activity, rotational mechanism ATP6V1A,ATP5E,ATP6AP1,ATPV0E2,ATP6V0E,ATP6V1B2,ATP6V1AA,ATP5B,ATP5A1,ATP6V0E2
    contributes_to ATPase activity ATP5C1,ATP5L,RFC3,ATP5B,ABCA7,ATP5O,ATP5J,ATP1A2,ATP5I,MSH2
    protein binding TMSB10,PLEKHH2,UNC13D,MRPL15,AP1S2,BRCA2,EPM2AIP1,TUBB2B,TCEA1,L3MBTL1

    Interacting Protein

    ATP6V1H has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V1H here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V1H.

    PTP4A3;MYC;PHLDA3;ETHE1;SOX9;yjjK;TANK;pi3p;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;15-deoxy-delta(12,14;ATP6V1A

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