Recombinant Full Length Human AP5Z1 Protein, GST-tagged

• Cat.No.: AP5Z1-1089HF
• Product Overview: Human AP5Z1 full-length ORF ( AAH37399, 1 a.a. - 446 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene was identified by genome-wide screen for genes involved in homologous recombination DNA double-strand break repair (HR-DSBR). The encoded protein was found in a complex with other proteins that have a role in HR-DSBR. Knockdown of this gene reduced homologous recombination, and mutations in this gene were found in patients with spastic paraplegia. It was concluded that this gene likely encodes a helicase (PMID:20613862). [provided by RefSeq, Jan 2011]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 74.8 kDa
• Protein length: 446 amino acids
• AA Sequence: MAKVVVLSPG TLQEDQATLL SKRLVDWLRY ASLQQGLPHS GGFFSTPRAR QPGPVTEVDG AVATDFFTVL SSGHRFTDDQ WLNVQAFSML RAWLLHSGPE GPGTLDTDDR SEQEGSTLSV ISATSSAGRL LPPRERLREV AFEYCQRLIE QSNRRALRKG DSDLQKACLV EAVLVLDVLC RQDPSFLYRS LSCLKALHGR VRGDPASVRV LLPLAHFFLS HGEAAAVDSE AVYQHLFTRI PVEQFHSPML AFEFIQFCRD NLHLFSGHLS TLRLSFPNLF KFLAWNSPPL TSEFVALLPA LVDAGTALEM LHALLDLPCL TAVLDLQLRS APAASERPLW DTSLRAPSCL EAFRDPQFQG LFQYLLRPKA SGATERLAPL HQLLQPMAGC ARVAQCAQAV PTLLQAFFSA VTQVADGSLI NQLALLLLGR SDSLYPAPGY AAGVHR
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: AP5Z1 adaptor related protein complex 5 zeta 1 subunit [ Homo sapiens (human) ]
• Official Symbol: AP5Z1
• Synonyms: AP5Z1; adaptor related protein complex 5 zeta 1 subunit; zeta; SPG48; KIAA0415; AP-5 complex subunit zeta-1; adapter-related protein complex 5 zeta subunit; adaptor-related protein complex 5 zeta subunit; zeta5
• Gene ID: 9907
• mRNA Refseq: NM_014855
• Protein Refseq: NP_055670
• MIM: 613653
• UniProt ID: O43299