Recombinant Full Length Human AKR7A2 Protein, GST-tagged

• Cat.No.: AKR7A2-1377HF
• Product Overview: Human AKR7A2 full-length ORF ( AAH04111.3, 1 a.a. - 330 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 61.82 kDa
• Protein length: 330 amino acids
• AA Sequence: MSRPPPPRVA SVLGTMEMGR RMDAPASAAA VRAFLERGHT ELDTAFMYSD GQSETILGGL GLGLGGGDCR VKIATKANPW DGKSLKPDSV RSQLETSLKR LQCPQVDLFY LHAPDHGTPV EETLHACQRL HQEGKFVELG LSNYASWEVA EICTLCKSNG WILPTVYQGM YNATTRQVET ELFPCLRHFG LRFYAYNPLA GGLLTGKYKY EDKDGKQPVG RFFGNSWAET YRNRFWKEHH FEAIALVEKA LQAAYGASAP SVTSAALRWM YHHSQLQGAH GDAVILGMSS LEQLEQNLAA TEEGPLEPAV VDAFNQAWHL VAHECPNYFR
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) [ Homo sapiens ]
• Official Symbol: AKR7A2
• Synonyms: AKR7A2; aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase); aflatoxin B1 aldehyde reductase member 2; AFAR; AFB1-AR 1; SSA reductase; aldoketoreductase 7; AFB1 aldehyde reductase 1; succinic semialdehyde reductase; aflatoxin beta1 aldehyde reductase; AKR7; AFAR1; AFB1-AR1
• Gene ID: 8574
• mRNA Refseq: NM_003689
• Protein Refseq: NP_003680
• MIM: 603418
• UniProt ID: O43488