Recombinant Equine Interleukin 17A

Cat. No. :	IL17A-254E
Description :	Interleukin-17A is a protein that in humans is encoded by the IL17A gene. The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Source :	Yeast.
Formulation/ Reconstitution :	Lyophilized. Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
Purification :	Ion-exchange chromatography.
Purity :	>95% as visualized by SDS-PAGE analysis.
Amino Acid Sequence :	GIVIPQNPEC PNTGDKNFPQ NVKINLNVLN RKTNSRRASD YHNRSTSPWN LHRNEDPERY PSVIWEAKCR HLGCVNAEGK VDFHMNSVPI QQEILVLRRE SQNCPHSFQL EKMLVAVGCT CVTPIVRHMG.
Bioactivity :	In testing.
Stability And Storage :	Stable for up to twelve months from date of receipt at -20°C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.
Tag :	Non

Gene Name	IL17A interleukin 17A [ Equus caballus ]
Synonyms	interleukin 17A; IL17A; IL17; interleukin 17
Gene ID	100034142
mRNA Refseq	NM_001143792.1
Protein Refseq	NP_001137264.1
Chromosome Location	20
Pathway	Cytokine-cytokine receptor interaction

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