Recombinant EBV-EBNA1 Mosaic Protein, GST-tagged

• Cat.No.: Mosaic-733E
• Product Overview: This protein does contain a GST-tag. The mosaic protein contains fragments of HHV-4 EBNA1 nuclear protein, amino acids: 1-90 and 408-498. The protein is purified by proprietary chromatographic technique.

Specification

• Species: HHV4
• Source: E.coli
• Tag: GST
• Description: The Epstein-Barr virus (EBV), a gamma herpesvirus, persists in B lymphocytes for the life of the host. EBNA1 (Epstein-Barr virus nuclear antigen 1) is expressed in every form of EBV-related malignancy, including posttransplant lymphomas. Tumors such as nasopharyngeal cell carcinoma, Hodgkin's lymphoma, and Burkitt's lymphoma (BL) that fail to express some or all of the dominant CD8+ T-cell latent antigens still express EBNA1. A significant proportion of memory CD4+ T-cells that recognize lymphoblastoid cell lines (LCLs) are directed against the EBNA1 protein. The EBNA1 protein contains a glycine-alanine repeat that prevents proper processing and presentation through the major histocompatibility complex class I (MHC I) pathway.
• Form: 50 mM Tris-HCl pH 8.0, 10 mM glutathione, 60 mM NaCl and 0.5% sarcosyl
• Molecular Mass: 46 kDa
• Purity: > 95 % (SDS-PAGE)
• Applications: ELISA; Western Blot
• Storage: Store at -20 centigrade, avoid freeze/thaw cycles.

Gene Information

• Official Symbol: Mosaic
• Synonyms: Mosaic