Recombinant Dog Crebbp Protein, His tagged

• Cat.No.: CREBBP-01D
• Product Overview: Recombinant Dog Crebbp Protein with His tag was expressed in HEK293.

Specification

• Description: This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Source: HEK293
• Species: Dog
• Tag: His
• Molecular Mass: The protein has a calculated MW of 44 kDa.
• AA Sequence: HHHHHHHHKFSAKRLQTTRLGNHLE DRVNKFLRRQNHPEAGEVFVRVVAS SDKTVEVKPGMKSRFVDSGEMSESF PYRTKALFAFEEIDGVDVCFFGMHV QEYGSDCPPPNTRRVYISYLDSIHF FRPRCLRTAVYHEILIGYLEYVKKL GYVTGHIWACPPSEGDDYIFHCHPP DQKIPKPKRLQEWYKKMLDKAFAER IIHDYKDIFKQATEDRLTSAKELPY FEGDFWPNVLEESIKELEQEEEERK KEESTAASETTEGSQGDSKNAKKKN NKKTNKNKSSISRANKKKPSMPNVS NDLSQKLYATMEKHKEVFFVIHLHA GPVINTLPPIVDPDPLLSCDLMDGR DAFLTLARDKHWEFSSLRRSKWSTL CMLVELHTQGQ
• Endotoxin: < 1 EU/μg by LAL
• Purity: > 90% by SDS-PAGE
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 0.36 mg/mL by BCA
• Storage Buffer: PBS, pH 7.4, 1% SKL

Gene Information

• Gene Name: CREBBP CREB binding protein [ Canis lupus familiaris ]
• Official Symbol: CREBBP
• Synonyms: CREBBP; CREB binding protein; CREB-binding protein; CREB binding protein (Rubinstein-Taybi syndrome)
• Gene ID: 479866
• mRNA Refseq: XM_038667646
• Protein Refseq: XP_038523574
• UniProt ID: A0A8C0YZ36

Reviews

04/17/2021

The product's adaptability to custom protocols empowered us to explore innovative experimental setups.

01/29/2019

The reduced environmental impact of the product was a responsible choice that resonated with our values.

11/15/2016

Customized solutions offered by the manufacturer increased the product's utility in our research.

Q&As

Why is the discovery of new CREBBP inhibitors urgent?

Discovering novel CREBBP inhibitors is crucial due to the limited number of reported inhibitors, and there is a need to enhance the activity and selectivity of existing compounds.

What is the significance of the bromodomain in CREBBP?

The bromodomain in CREBBP is linked to its involvement in cancer and other disease processes.

What does CREBBP stand for?

CREBBP stands for CREB-binding protein.

What is the role of CREBBP in cellular function?

CREBBP serves as a coactivator for the cAMP response element-binding protein (CREB) transcription factor. It plays a crucial role in gene activation.

What is the current status of CREBBP small molecule inhibitors?

Research on small molecule inhibitors of CREBBP is in its early stages, with only a few inhibitors reported. Improvements in activity and selectivity are needed for these compounds.

In which category of structural domain proteins does CREBBP belong?

CREBBP belongs to the third category of structural domain proteins, and it shares homology with its counterpart EP300.

How many structural domains does CREBBP have?

CREBBP contains a bromodomain, which is associated with the development of cancer and other diseases.