Recombinant Cynomolgus SIGLEC15 protein, His-Avi-tagged

• Cat.No.: SIGLEC15-190C
• Product Overview: Recombinant Cynomolgus siglec-15 Protein is expressed from mammalian with a Poly-His and Avi Tag at the C-terminal. It contains Phe 20 - Thr 263.

Specification

• Species: Cynomolgus
• Source: HEK293
• Tag: His&Avi
• ProteinLength: It contains Phe 20 - Thr 263 .
• Description: Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.
• Form: Supplied as 0.22um filtered solution in 20mM PB, 0.5M NaCl, 5% Glycerol,0.1M L-Arginine , pH 6.0.
• Molecular Mass: The Protein has a calculated MW of 29.7kDa . As a result of glycosylation, the protein migrates to 35-43kDa based on Bis-Tris PAGE.
• Endotoxin: Less than 0.5EU per ug by the LAL method.
• Purity: > 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: SIGLEC15 sialic acid binding Ig like lectin 15 [ Macaca fascicularis (crab-eating macaque) ]
• Official Symbol: SIGLEC15
• Synonyms: CD33 antigen-like 3 SIGLEC-15; CD33 molecule-like 3; CD33L3; HsT1361; sialic acid binding Ig-like lectin 15; sialic acid-binding Ig-like lectin 15; Siglec15; Siglec-15
• Gene ID: 102126346
• mRNA Refseq: XM_005586809.2
• Protein Refseq: XP_005586866.1