Recombinant Cynomolgus CD160, His-tagged

• Cat.No.: CD160-114C
• Product Overview: A DNA sequence encoding the cynomolgus CD160 (Met1-Leu158) was expressed with a polyhistidine tag at the C-terminus.

Specification

• Species: Cynomolgus
• Source: Human Cells
• Tag: His
• Protein Length: 1-158 a.a.
• Description: CD160 antigen, also known as Natural killer cell receptor BY55 and CD160, is a cell membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. CD160 is a GPI-anchored lymphocyte surface receptor in which expression is mostly restricted to the highly cytotoxic CD56(dim)CD16(+) peripheral blood NK subset. CD160 is a receptor showing broad specificity for both classical and non-classical MHC class I molecules. CD160 is expressed in spleen, peripheral blood, and small intestine. Expression of CD160 is restricted to functional NK and T cytotoxic lymphocytes. CD160 acts as a co-activator receptor for CD3-induced proliferation of CD4+ CD160+ T cells isolated from inflammatory skin lesions. Unique CD4+ CD160+ lymphocyte subset may play a role in the pathogenesis of skin inflammation. Activated NK lymphocytes release a soluble form of CD160 that functionally impairs the MHC-I-specific cytotoxic CD8(+) T lymphocyte responsiveness.
• Predicted N Terminal: Gly 25
• Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.
• Molecular Mass: The recombinant cynomolgus CD160 comprises 145 amino acids and has a calculated molecular mass of 16.3 KDa. The apparent molecular mass of it is approximately 25 and 22 KDa respectively in SDS-PAGE.
• Endotoxin: < 1.0 eu per ug of the protein as determined by the lal
• Purity: (70+22.5)% as determined by SDS-PAGE
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.