Recombinant COVID-19 S2 protein, Fc-tagged

• Cat.No.: S2-138V
• Product Overview: Recombinant COVID-19 S2 protein, fused to Fc-tag at the C-terminus, was expressed in Human Cells and purified by affinity purification chromatography.

Specification

• Species: COVID-19
• Source: Human Cells
• Tag: Fc
• Description: Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that COVID-19 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
• Form: Supplied as a 0.2 μM filtered solution of PBS, pH7.4.
• Molecular Mass: Mol Mass: 84.1 kDa; AP Mol Mass: 100-130 kDa, reducing conditions.
• Purity: Greater than 95% as determined by reducing SDS-PAGE.
• Applications: Immunogen, calibrator or standard.
• Storage: Reconstituted protein solution should be stored at ≤ -20 centigrade.
• Shipping: The product is shipped on dry ice pack. Upon receipt, store it immediately at the temperature listed below.
• Warning: FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY

Gene Information

• Gene Name: S
• Official Symbol: S
• Synonyms: GU280_gp02
• Gene ID: 43740568
• Protein Refseq: YP_009724390.1