Recombinant Bovine PIK3R2 (Beta)

• Cat.No.: PIK3R2-180B

Specification

• Cat. No.: PIK3R2-180B
• Description: p85α acts as regulatory subunit of the class IA PI3-kinase isoforms α, β, and δ. It contains two SH2 domains that bind to tyrosine-phosphorylated growth factor receptors or substrate adaptor proteins. It also contains a BH (breakpoint cluster region homology) domain that shows GAP activity towards the small GTPases Rab4, Rab5, Cdc42, Rac1 and to a lesser extend towards Rab6 and Rab11. MW=83.5kDa.
• Source: Sf9 insect cells.
• Form: Liquid. Supplied in 50mM Tris-HCl pH7.5, 50mM NaCl and 50% glycerol.
• Purity: >95% by SDS-PAGE.
• Usage: For in vitro use only.
• Storage: Quality guaranteed for 12 months. Store at -80℃. Avoid freeze / thaw cycles.
• Tag: Non

Gene Information

• Gene Name: PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) [ Bos taurus ]
• Synonyms: PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta); MGC138113; phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta); phosphoinositide-3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
• Gene ID: 282308
• mRNA Refseq: NM_174576
• Protein Refseq: NP_777001
• UniProt ID: P23726
• Chromosome Location: 7
• Pathway: Acute myeloid leukemia; Apoptosis; B cell receptor signaling pathway; Chemokine signaling pathway; Chronic myeloid leukemia; Colorectal cancer; Endometrial cancer; ErbB signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Focal adhesion; Glioma; Insulin signaling pathway; Jak-STAT signaling pathway; Leukocyte transendothelial migration; Melanoma; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Non-small cell lung cancer; Pancreatic cancer; Pathways in cancer; Phosphatidylinositol signaling system; Prostate cancer; Regulation of actin cytoskeleton; Renal cell carcinoma; Small cell lung cancer; T cell receptor signaling pathway; Toll-like receptor signaling pathway; Type II diabetes mellitus; VEGF signaling pathway; mTOR signaling pathway
• Function: 1-phosphatidylinositol-3-kinase activity; phosphoinositide 3-kinase regulator activity; protein binding