Recombinant Bacillus subtilis subsp. subtilis str. 168 oxalate decarboxylase, His tagged

• Cat.No.: oxdC-10BFL
• Product Overview: Recombinant Bacillus subtilis subsp. subtilis str. 168 oxalate decarboxylase with His tag was expressed in HEK293.

Specification

• Description: N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. NNMT is an important cytosolic methyltransferase catalyzing the N-methylation of nicotinamide, pyridines and structural analogs, playing a crucial role in the biotransformation and detoxification of many xenobiotic compounds. In the N-methylation process, NNMT uses S-adenosyl methionine as the methyl donor and nicotinamide as methyl acceptor. NNMT is mostly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. It may also play an important role in regulating biological processes related to N-methyl nicotinamide such as anti-inflammatory, anti-thrombotic, vasoprotective, and gastroprotective properties. Increased NNMT activity was reported in many kinds of tumors. NNMT is a potential biomarker and therapeutic target in caner diagnosis and treatment. NNMT serum levels have significance in the premature detection and in the management of patients with colorectal cancer.
• Source: HEK293
• Species: Bacillus subtilis subsp. subtilis str. 168
• Tag: N-6×His
• Protein length: 1-385aa
• Form: Liquid
• Bio-activity: Specific activity with 100 mM oxalate is approximately 150 U/mg. (Specific activity is calculated by oxalate decarboxylase activity colorimetric assay kit.)
• Molecular Mass: 45.9 kDa
• Purity: ≥98% (SDS-PAGE)
• Storage: At -70 centigrade.
• Concentration: 2 mg/mL
• Storage Buffer: HEPES Buffer containing 20% glycerol.

Gene Information

• Gene Name: oxdC oxalate decarboxylase [ Bacillus subtilis subsp. subtilis str. 168 ]
• Official Symbol: oxdC
• Synonyms: oxdC; oxalate decarboxylase; oxalate decarboxylase; EC 4.1.1.2; Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181; Product type e : enzyme
• Gene ID: 938620
• Protein Refseq: NP_391204
• UniProt ID: O34714