Recombinant Anti-Human IL 12B Monoclonal Antibody

• Cat.No.: CAB-T9002H
• Product Overview: Mab to IL12B. Recombinant monoclonal antibody to Human IL 12B.

Specification

• Species: Human
• Tag: Non
• Antigen Description: Cytokine that can act as a growth factorfor activated T and NK cells, enhance the lytic activity ofNK/lymphokine-activated Killer cells, and stimulate the production ofIFN-gamma by resting PBMC.
• Protein Costruction: DNA sequences codingH and L chains of Anti-human interleukin-12/23 monoclonal antibody cotransfected to host cell were expressed.
• Isotype: IgG
• Formulation: Normally 1mg/mlL-His, 1mg/ml Sucrose and 0.04 mg/ml Tween-80 are added, pH 6.0. Pleasecontact us for any concerns or special requirements.
• Purity Detail: >95% asdetermined by SDS-PAGE and HPLC
• Expression Host: Chinese HamsterOvary (CHO cell)
• Endotoxin: <1.0EUper 10 mg protein as determined by the LAL method
• Molecular Mass: The secretedrecombinant Anti-human interleukin-12/23 monoclonal antibody comprises 1326amino acids. As a result of glycosylation, it has molecular mass of 150kDa inSDS-PAGE under non-reducing conditions.
• Predicted N terminal: H chain: EVQLVQSGAE;Lchain:DIQMTQSPSS
• Stability: Samples are stablefor up to twelve months from date of receipt at -20°C and are stable forsix months at 4°C.
• Storage: Store it understerile conditions at -70°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
• Background: The recombinant antibody targets the epitope of IL12. Like Briakinumab or ustekinumab,whichis directed against interleukin 12 naturally occurring proteins that regulatethe immune system and immune-mediated inflammatory disorders. Anti-humaninterleukin-12/23 monoclonal antibody is a human IgG1 monoclonal antibodythat binds to subunit of p40, which is used by IL-12 and IL-23. It isproduced in Chinese hamster ovary (CHO) cells.

Gene Information

• Gene Name: IL12B interleukin 12B(natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturationfactor 2, p40) [ Homo sapiens ]
• Official Symbol: IL12B
• Synonyms: IL12B; CLMF; NKSF; CLMF2; NKSF2; IL-12B;interleukin 12B (natural killer cell stimulatory factor 2, cytotoxiclymphocyte maturation factor 2, p40); interleukin-12 subunit beta CLMF p40; IL-12 subunit p40; IL12, subunit p40; OTTHUMP00000160820;interleukin 12, p40; interleukin-12 beta chain; NK cell stimulatory factorchain 2; cytotoxic lymphocyte maturation factor 40 kDa subunit; naturalkiller cell stimulatory factor, 40 kD subunit
• Gene ID: 3593
• mRNA Refseq: NM_002187
• Protein Refseq: NP_002178
• MIM: 161561
• UniProt ID: P29460
• Chromosome Location: 5q31.1-q33.1
• Pathway: African trypanosomiasis, organism-specific biosystem; Africantrypanosomiasis, conserved biosystem; Allograft rejection, organism-specificbiosystem; Allograft rejection, conserved biosystem; Amoebiasis,organism-specific biosystem; Amoebiasis, conserved biosystem; Chagas disease(American trypanosomiasis), organism-specific biosystem; Chagas disease (Americantrypanosomiasis), conserved biosystem; Cytokine-cytokine receptorinteraction, organism-specific biosystem; Cytokine-cytokine receptorinteraction, conserved biosystem; Cytokines and Inflammatory Response,organism-specific biosystem
• Function: contributes_tocytokine activity; cytokine receptor activity; contributes_to growth factoractivity; identical protein binding; interleukin-12 alpha subunit binding; interleukin-12receptor binding; contributes_to interleukin-12 receptor binding; contributes_tointerleukin-23 receptor binding; protein binding; protein heterodimerizationactivity; protein homodimerization activity; signal transducer activity