Rabbit Monoclonal Antibody to Human Myelin Oligodendrocyte Glycoprotein
Cat.No. : | CAB11583RH |
Product Overview : | Rabbit Monoclonal Antibody to Human Myelin Oligodendrocyte Glycoprotein |
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Species : | Human |
Source : | Rabbit |
Tag : | Non |
Antigen Description : | Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to immunoglobulin superfamily, and contains an Ig-like domain followed by two potential membrane-spanning regions. MOG is expressed only in the CNS with very low content (approximately 0.1% total proteins) in oligodendrogliocyte membrane. Three possible functions for MOG were suggested: (a) a cellular adhesive molecule, (b) a regulator of oligodendrocyte microtubule stability, and (c) a mediator of interactions between myelin and the immune system, in particular, the complement cascade. A direct interaction might exist between the membrane-associated regions of MOG and the myelin-specific glycolipid galactocerebroside (Gal-C), and such an interaction may have important consequences regarding the membrane topology and function of both molecules. It is considered that MOG is an autoantigen capable to produce a demyelinating multiple sclerosis-like disease in experimental animals. |
Specificity : | Human MOG. No cross-reactivity with human cell lysate ( 293 cell line ) in WB and ELISA. |
Immunogen : | Recombinant Human MOG Protein |
Isotype : | Rabbit IgG |
Clone : | A014 |
Applications : | Western blot; ELISA |
Dilution : | Western blot: This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human MOG in WB.Direct ELISA: This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human MOG. The detection limit for Human MOG is approximately 0.00975 ng/well. |
Preparation : | This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant Human MOG |
Format : | 0.2 μm filtered solution in PBS with 5% trehalose |
Storage : | This antibody can be stored at 2-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 to -70 °C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
Gene Name | MOG myelin oligodendrocyte glycoprotein [ Homo sapiens ] |
Official Symbol | MOG |
Synonyms | MOG; myelin oligodendrocyte glycoprotein; myelin-oligodendrocyte glycoprotein; MOG Ig-AluB; MOG alpha-5; MOGIG2; NRCLP7; MGC26137; |
Gene ID | 4340 |
mRNA Refseq | NM_001008228 |
Protein Refseq | NP_001008229 |
MIM | 159465 |
UniProt ID | Q16653 |
Chromosome Location | 6p22-p21.3 |
◆ Native Proteins | ||
MOG-20 | Native Mouse/Rat MOG (35-55) Protein | +Inquiry |
◆ Cell & Tissue Lysates | ||
MOG-1126HCL | Recombinant Human MOG cell lysate | +Inquiry |
Not For Human Consumption!
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