Rabbit Anti-Human CD48 Molecule Monoclonal Antibody

• Cat.No.: CAB11502RH
• Product Overview: Rabbit monoclonal antibody to human CD48 molecule.

Specification

• Antigen Description: CD48, also known as SLAMF2, BCM-1 and BLAST-1, is a 65 kDa GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfamily molecules. In rodents, CD48 is the ligand for CD2 whereas in humans, CD58 is the ligand for CD2. Human CD48 cDNA encodes a 243 aa precursor that includes a 26 aa signal sequence, a 194 aa mature protein that contains one Ig-like V-type domain and one Ig-like C2-type domain, and a 23 aa C-terminal propeptide. It has a high degree of sequence homology to CD58 (LFA-3), and human CD48 shares approximately 50% aa sequence identity with mouse and rat CD48. CD48 is expressed on most lineage-committed hematopoietic cells but not on hematopoietic stem cells or multipotent hematopoietic progenitors. CD48 performs biological functions in a variety processes including adhesion, pathogen recognition, cellular activation, and cytokine regulation, and emerges as a critical effector molecule in immune responses.
• Specificity: Human CD48 / SLAMF2. No cross-reactivity in ELISA with Mouse CD48, Human TNFRSF4.
• Immunogen: Recombinant Human CD48 / SLAMF2 Protein
• Host: Rabbit
• Isotype: Rabbit IgG
• Species: Human
• Clone: 010
• Applications: Western Blot
• Dilution: Western blot: This antibody can be used at 1 - 2 μg/mL with the appropriate secondary reagents to detect Human CD48 in WB. Using a DAB detection system, the detection limit for Human CD48 is approximately 2 ng/lane under non-reducing conditions and 1 ng/lane under reducing conditions.
• Preparation: This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant Human CD48 / SLAMF2.
• Format: 0.2 μm filtered solution in PBS with 5% trehalose
• Storage: This antibody can be stored at 2-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
• Tag: Non

Gene Information

• Gene Name: CD48 CD48 molecule [ Homo sapiens ]
• Official Symbol: CD48
• Synonyms: CD48; CD48 molecule; BCM1,CD48 antigen (B cell membrane protein) ,CD48 molecule; CD48 antigen; BLAST; hCD48; mCD48; SLAMF2; TCT.1; BCM1 surface antigen; leukocyte antigen MEM-102; B-lymphocyte activation marker BLAST-1; CD48 antigen (B-cell membrane protein); BCM1; BLAST1; MEM-102
• Gene ID: 962
• mRNA Refseq: NM_001256030
• Protein Refseq: NP_001242959
• MIM: 109530
• UniProt ID: P09326
• Chromosome Location: 1q21.3-q22
• Pathway: Cell surface interactions at the vascular wall, organism-specific biosystem; Hemostasis, organism-specific biosystem; Natural killer cell mediated cytotoxicity, organism-specific biosystem; Natural killer cell mediated cytotoxicity, conserved biosystem
• Function: antigen binding; eukaryotic cell surface binding; protein binding; receptor activity