| Species : |
Human |
| Source : |
Rabbit |
| Tag : |
Non |
| ProductOverview : |
Monoclonal Antibody toCD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. |
| Antigen Description : |
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. |
| Clone : |
FQS7277 |
| Host animal : |
Rabbit |
| CrossReactivity : |
Human |
| Isotype : |
IgG1 |
| Immunogen : |
Recombinant fragment corresponding to the extracellular domain of Human CD4 |
| Positive control : |
Human fetal thymus and Human lymph node lysates, THP-1 cells |
| Application : |
WB; ICC/IF; Flow Cyt |
| Sequencesimilarities : |
Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
| Post-translationalmodifications : |
Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts. |
| Cellular localization : |
Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum. |
| Form : |
Liquid |
| Purity : |
Tissue culture supernatant |
| Storage Buffer : |
pH: 7.40; Preservative: 0.01% Sodium azide; Constituents: 49% PBS, 50% Glycerol, 0.05% BSA |
| Storage : |
Store at -20°C. Stable for 12 months at -20°C |
| nullValue_other : |
| Function | MHC class II protein binding; coreceptor activity; enzyme binding; extracellular matrix structural constituent; glycoprotein binding; protein binding; protein homodimerization activity; protein kinase binding; receptor activity; transmembrane signaling receptor activity; zinc ion binding |
|
