Native Human Uromodulin Protein

Specification
Gene Information
Related Products
Download

Cat. No. :	UMOD-1881H
Description :	Uromodulin is the most abundant protein in normal urine. Its secretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin plays a role as a constitutive inhibitor of calcium crystallization in renal fluids. Secretion of uromodulin in urine provides protection against urinary tract infections caused by uropathogenic bacteria. Defects in Uromodulin expression are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. UMOD is involved in regulating the circulating activity of cytokines as it binds to il-1, il-2 and tnf with high affinity.
Source :	Human Urine.
Physical Appearance :	Filtered White lyophilized (freeze-dried) powder.
Purity :	Greater than 95.0% as determined by SDS-PAGE.
Formulation :	The UMOD protein was lyophilized from 0.4µm filtered solution at a concentration of 0.6mg/mL containing water.
Stability :	Lyophilized UMOD although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution UMOD should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Tag :	Non

Gene Name	UMOD uromodulin [ Homo sapiens ]
Synonyms	Uromodulin; THP; FJHN; HNFJ; THGP; HNFJ1; MCKD2; ADMCKD2; UMOD; uromucoid; Tamm-Horsfall glycoprotein; tamm-Horsfall urinary glycoprotein; uromodulin (uromucoid, Tamm-Horsfall glycoprotein); Tamm-Horsfall urinary glycoprotein
Gene ID	7369
mRNA Refseq	NM_001008389.1
Protein Refseq	NP_001008390.1
MIM	191845
UniProt ID	P07911
Chromosome Location	16p12.3
Function	calcium ion binding