Native Human Haptoglobin

• Cat.No.: HP-4387H
• Product Overview: Human HP produced from pooled human plasma corresponding to the Mw of isotypes of HP at 86kD and 200kD.

Specification

• Species: Human
• Source: Human Plasma
• Tag: Non
• Description: HP is a glycoprotein which is synthesized in the liver and circulates in the blood. HP is produced typically by hepatocytes but also by other tissues: e.g. skin, lung, and kidney. It is a positive acute phase protein that binds free hemoglobin and removes it from the circulation to prevent kidney injury, and iron loss following hemolysis. The HP-hemoglobin complex is subsequently removed by the reticuloendothelial system (generally the spleen). As the reticuloendothelial system removes the HP-hemoglobin complex from the body, HP levels are reduced in hemolytic anaemias. In the course of binding hemoglobin, HP sequesters the iron inside hemoglobin, preventing iron-utilizing bacteria from benefitting from hemolysis.
• Form: Lyophilized from 0.02M NH4HCO3. May contain traces of buffer salts.
• Purity: Greater than 96.0%.
• Storage: Human HP although stable at room temperature for 3 weeks, should be stored between 2-8°C.

Gene Information

• Gene Name: HP haptoglobin [ Homo sapiens ]
• Official Symbol: HP
• Synonyms: HP; haptoglobin; zonulin; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, beta polypeptide; haptoglobin, alpha polypeptide; BP; HPA1S; HP2ALPHA2; MGC111141
• Gene ID: 3240
• mRNA Refseq: NM_001126102
• Protein Refseq: NP_001119574
• MIM: 140100
• UniProt ID: P00738
• Chromosome Location: 16q22.2
• Pathway: amb2 Integrin signaling, organism-specific biosystem
• Function: catalytic activity; hemoglobin binding; serine-type endopeptidase activity