Native Human Cathepsin B

• Cat.No.: CTSB-1647H
• Product Overview: Native Human Cathepsin B was purified from Human Liver.

Specification

• Species: Human
• Source: Human Liver
• Tag: Non
• Description: Cathepsin B , a cysteine proteinase, is located in lysosomes and is involved in tissue degradation and restructuring. Specifically, cathepsin B is believed to be involved in the intracellular digestion of extracellular proteins taken up by endocytosis.
• Form: Frozen in 50 mM Na Acetate, pH 5.0, with 1 mM EDTA.
• Bio-activity: Greater than 200 units per mg protein. One unit is defined as the amount of enzyme that hydrolyzes one umole of Z-Arg-Arg-beta-naphthylamide per minute at 40oC, using 100 mM Na/K phosphate, pH 6.0, with 1.33 mM EDTA and 2 mM DTT as the activation buffer.
• Molecular Mass: 27500
• Purity: ≥95% by SDS-PAGE
• Storage: -70°C or lower

Gene Information

• Gene Name: CTSB cathepsin B [ Homo sapiens ]
• Official Symbol: CTSB
• Synonyms: CTSB; cathepsin B; cathepsin B1; APP secretase; cysteine protease; amyloid precursor protein secretase; APPS; CPSB
• Gene ID: 1508
• mRNA Refseq: NM_001908
• Protein Refseq: NP_001899
• MIM: 116810
• UniProt ID: P07858
• Chromosome Location: 8p23.1
• Pathway: Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Toll Receptor Cascades, organism-specific biosystem
• Function: cysteine-type endopeptidase activity; cysteine-type peptidase activity; kininogen binding; peptidase activity; peptide binding; protein binding