Native Human Catalase Protein

• Cat.No.: CAT-1646H
• Product Overview: Native Human Catalase purified from Erythrocytes.

Specification

• Species: Human
• Source: Erythrocytes
• Description: This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer''s disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene.
• Form: Homotetramer
• Molecular Mass: 230 kDa
• Extinction Coefficient: 1.39
• Bio-Activity: Greater than 50,000 units per mg protein. One unit is equal to the amount of enzyme that will decompose one micromole of hydrogen peroxide per minute at 25 centigrade, pH 7.0
• Purity: > =95% by SDS-PAGE
• Stability: > 1 year
• Storage: ≤ -70 centigrade
• Storage Buffer: Frozen in 50 mM Tris-HCl, pH 8.0.
• Reference: 1. Xiao, Wusheng, Yueming Zhu, Ehab H. Sarsour, Amanda L. Kalen, Nukhet Aykin-Burns, Douglas R. Spitz, and Prabhat C. Goswami. "Selenoprotein P regulates 1-(4-Chlorophenyl)-benzo-2, 5-quinone induced oxidative stress and toxicity in human keratinocytes." Free Radical Biology and Medicine (2013)

Gene Information

• Gene Name: CAT catalase [ Homo sapiens (human) ]
• Official Symbol: CAT
• Synonyms: CAT; catalase; epididymis secretory sperm binding protein; EC 1.11.1.6
• Gene ID: 847
• mRNA Refseq: NM_001752
• Protein Refseq: NP_001743
• MIM: 115500
• UniProt ID: P04040