Native Human Apolipoprotein CII

Description :	This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene.
Source :	Human Plasma
Species :	Human
Form :	Lyophilized from 10 mM NH4HCO3, pH 7.4
Molecular Mass :	8800
Purity :	>=95% by SDS-PAGE
Quality Control Test :	Shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
Stability :	> 1 Year
Storage :	-20°C
Tag :	Non

Gene Name	APOC2 apolipoprotein C-II [ Homo sapiens (human) ]
Official Symbol	APOC2
Synonyms	APOC2;apolipoprotein C-II; APO-CII; APOC-II; MGC75082; apolipoprotein C2; apoC-II; Apolipoprotein C2; APC2; Apo-CII; apo-CII; ApoC-II
Gene ID	344
mRNA Refseq	NM_000483
Protein Refseq	NP_000474
MIM	608083
UniProt ID	P02655
Chromosome Location	19q13.2
Pathway	Chylomicron-mediated lipid transport; HDL-mediated lipid transport; Lipid digestion; Lipoprotein metabolism; Metabolism of lipids and lipoproteins; Statin Pathway
Function	enzyme activator activity; lipase inhibitor activity; lipid binding; lipoprotein lipase activator activity; phospholipase activator activity; phospholipase binding; protein homodimerization activity