Mouse Anti-IL1RN Monoclonal Antibody

• Cat.No.: DMABT-H18692
• Product Overview: Mouse Anti-IL1RN Monoclonal Antibody

Specification

• Antigen Description: Interleukin-1 receptor antagonist (IL-1RA) is composed of three isoforms, one secreted (sIL-1Ralpha/IL-1Ralpha1), two intracellular (IL-1Ralpha2/IL-1Ralpha3) and produced by monocytes, tissue macrophages, Langerhans cells, dendritic cells, T and B cells, natural killer (NK) cells, large granular lymphocytes (LGL), vascular endothelium, smooth muscle, fibroblasts, thymic epithelia, astrocytes, microglia, glioma cells, keratinocytes, and chondrocytes. It is upregulated by IL-1beta, IL-4, IL-6 and downregulated by glucocorticoids.
• Target: IL1RN
• Immunogen: Recombinant human IL-1 receptor antagonist
• Host: Mouse
• Isotype: IgG1
• species: Human
• Clone: KL2SB-2
• Conjugation: N/A
• Applications: ELISA
• Preparation: The antibody was purified by affinity chromatography.
• Usage recommendation: Each lot of this antibody is quality control tested by ELISA assay. For ELISA capture applications, a concentration range of 4-6 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
• Concentration: 0.5 mg/ml
• Storage: The antibody solution should be stored undiluted at 4 °C.
• Size: 50 μg;500 μg
• Tag: Non

Gene Information

• Gene Name: IL1RN interleukin2receptor antagonist [ Homo sapiens ]
• Official Symbol: IL1RN
• Synonyms: IL1RN; interleukin2receptor antagonist; interleukin-1 receptor antagonist protein; ICIL 1RA; IL 1RN; IL1F3; IL1RA; interleukin2receptor antagonist protein; intracellular interleukin2receptor antagonist; IRAP; MGC10430; IL1 inhibitor; IL1RN (IL1F3); type II interleukin-1 receptor antagonist; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); DIRA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA
• Gene ID: 3557
• mRNA Refseq: NM_000577
• Protein Refseq: NP_000568
• MIM: 147679
• UniProt ID: P18510
• Chromosome Location: 2q14.2
• Pathway: Cytokine Signaling in Immune system, organism-specific biosystem; IL-1 Signaling Pathway, organism-specific biosystem; IL1-mediated signaling events, organism-specific biosystem; Immune System, organism-specific biosystem; Interleukin-1 signaling, organism-specific biosystem; Signaling by Interleukins, organism-specific biosystem
• Function: interleukin-1 Type I receptor antagonist activity; interleukin-1 Type II receptor antagonist activity; interleukin-1 receptor antagonist activity; interleukin-1 receptor antagonist activity; interleukin-1 receptor binding; interleukin-1, Type I receptor binding; interleukin-1, Type II receptor binding