Human Amylin, Amide

• Cat.No.: IAPP-001H
• Product Overview: CAS No. 122384-88-7
  C Terminal: NH2
  Disulfide Bridge: Cys2-Cys7
  Format Bridge: 2-7

Specification

• Species: Human
• Source: Synthetic
• Tag: Non
• Description: Amylin, a 37-amino acid polypeptide that is structurally related to calcitonin, is secreted from the B cells of the pancreas. Amylin has anoretic effects in rats. Amylin may be responsible for the etiology of insulin resistance of type II diabetes mellitus through its modulation of peripheral effects of insulin. Amylin blocks the activation of glycogen synthase by insulin.
• Molecular Mass: 3903.28 Da
• AA Sequence: Sequence: Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2
  Sequence Shortening: KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY-NH2
• Purity: > 95%
• Storage: Store at -20 centigrade. Keep container tightly closed. Store in a cool dry place.
• Reconstitution: Can be dissolved in DMSO or DMF first and then dilute with water
• Publications:
  Islet amyloid polypeptide aggregation exerts cytotoxic and proinflammatory effects on the islet vasculature in mice (2022)

Gene Information

• Gene Name: IAPP
• Official Symbol: IAPP islet amyloid polypeptide [ Homo sapiens (human) ]
• Synonyms: IAPP; islet amyloid polypeptide; DAP; IAP; islet amyloid polypeptide; Islet amyloid polypeptide (diabetes-associated peptide; amylin)
  amylin; diabetes-associated peptide; insulinoma amyloid peptide
• Gene ID: 3375
• mRNA Refseq: NM_000415
• Protein Refseq: NP_000406
• MIM: 147940
• UniProt ID: P10997