Goat Anti-Human DVL3 Polyclonal Antibody

• Cat.No.: CPBT-Y0051RH
• Product Overview: Goat Anti-Human DVL3 Polyclonal Antibody

Specification

• Species: Human
• Tag: Non
• Antigen Description: Mammalian homologs of the Drosophila dishevelled (Dsh) gene have been identified, including Dvl-1, Dvl-2 and Dvl-3. The mammalian dishevelled proteins contain three homologous domains, two of which are unrelated to any other known protein. The third region is homologous to the discs-large homology domain of Drosophila discs-large-1, a tumor suppressor protein. Like their Drosophila counterpart, the dishevelled proteins are thought to be in-volved in embryogenesis. Overexpression of Dvl-1 has been shown to inhibit the phosphorylation of tau by GSK-3b. This finding may prove to be important in Alzheimer's studies, which have shown that tau is hyperphosphorylated. In Drosophila, Dsh is a component of the frizzled signaling pathway. Both mammalian dishevelled and frizzled proteins are components of the Wnt signalling pathway.
• Target: DVL3
• Isotype: IgG
• species: Human
• Cross Reactivity: Mouse,Rat and Human
• Applications: WB, IP, IF and ELISA
• Storage: Store at 4° C, **DO NOT FREEZE**. Stable for one year from the date of shipment. Non-hazardous. No MSDS required.

Gene Information

• Gene Name: DVL3 dishevelled, dsh homolog 3 (Drosophila) [ Homo sapiens ]
• Official Symbol: DVL3
• Synonyms: DVL3; dishevelled, dsh homolog 3 (Drosophila); dishevelled 3 (homologous to Drosophila dsh); segment polarity protein dishevelled homolog DVL-3; KIAA0208; DSH homolog 3; dishevelled-3
• Gene ID: 1857
• mRNA Refseq: NM_004423
• Protein Refseq: NP_004414
• MIM: 601368
• UniProt ID: Q92997
• Chromosome Location: 3q27
• Pathway: Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Canonical Wnt signaling pathway, organism-specific biosystem; DNA damage response (only ATM dependent), organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Melanogenesis, organism-specific biosystem
• Function: beta-catenin binding; frizzled binding; protease binding; protein binding; protein heterodimerization activity; receptor binding; signal transducer activity