Recombinant Human FLNA, His-tagged

• Cat.No.: FLNA-28906TH
• Product Overview: Recombinant fragment, corresponding to amino acids 1730-2639 of Human Filamin A Isoform 2 with N terminal His Tag; Predicted MWt 97 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1730-2639 a.a.
• Description: The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.
• Conjugation: HIS
• Tissue specificity: Ubiquitous.
• Form: Lyophilised:Reconstitute with 111 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: VTALAGDQPSVQPPLRSQQLAPQYTYAQGGQQTWAPERPL VGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKV AQPTITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPG SPLQFYVDYVNCGHVTAYGPGLTHGVVNKPATFTVNTK DAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHVPGSPFTARVTGDDSMRMSHLKVGSAA DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHV GISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIG DASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLS IEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVANVGSHCD LSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYC IRFVPAEMGTHTVSVKYKGQHVPGSPFQFTVGPLGEGG AHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAV EGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASF AVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVR FIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDP GLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTID GPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAP QHGAPGPGPADASKVVAKGLGLSKAYVGQKSSFTVDCS KAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLK DKGEYTLVVKWGDEHIPGSPYRVVVP
• Sequence Similarities: Belongs to the filamin family.Contains 1 actin-binding domain.Contains 2 CH (calponin-homology) domains.Contains 24 filamin repeats.

Gene Information

• Gene Name: FLNA filamin A, alpha [ Homo sapiens ]
• Official Symbol: FLNA
• Synonyms: FLNA; filamin A, alpha; filamin A, alpha (actin binding protein 280) , FLN, FLN1, OPD1, OPD2; filamin-A; ABP 280; actin binding protein 280
• Gene ID: 2316
• mRNA Refseq: NM_001110556
• Protein Refseq: NP_001104026
• MIM: 300017
• Uniprot ID: P21333
• Chromosome Location: Xq28
• Pathway: Androgen Receptor Signaling Pathway, organism-specific biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-extracellular matrix interactions, organism-specific biosystem; Focal Adhesion, organism-specific biosystem
• Function: Fc-gamma receptor I complex binding; GTP-Ral binding; Rac GTPase binding; Rho GTPase binding; actin binding