Recombinant Human MSH2

• Cat.No.: MSH2-162H

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• ProteinLength: 735-934 a.a.
• ProductOverview: RecombinantHuman MSH2 protein expressed in E.coli encodes amino acids 735-934.
• Description: MSH2 (MutS homologue 2) is a 100-kDaprotein involved in mismatched nucleotides during DNA replication or repairprocess. MSH2 functions as one of the four major DNA mismatch repair genesalong with MLH1, PMS2 and PMS1. Somatic mutations in the human MSH2 genecontribute to the development of sporadic colorectal carcinomas whilegermline mutations are involved in a large number of colorectal carcinoma.
• Formulation: Recombinant Human MSH2 protein at 100µg/mlin 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
• ApplicationAnd Suggested Dilutions: •ELISA •Inhibition Assays •Western Blotting
• Characterization: MSH2 Antibody reactive.
• Storage & Stability: Store vial at -20℃ to -80℃. When stored at the recommended temperature,this protein is stable for 12 months.

Gene Information

• Gene Name: MSH2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) [ Homo sapiens ]
• Synonyms: MSH2;mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli); FCC1; COCA1;HNPCC; LCFS2; HNPCC1; mutS homolog 2; mutS (E. coli) homolog 2 (colon cancer,nonpolyposis type 1); DNA mismatch repair protein Msh2; MutS protein homolog2
• Gene ID: 4436
• mRNA Refseq: NM_000251
• Protein Refseq: NP_000242
• MIM: 609309
• UniProt ID: P43246
• Chromosome Location: 2p21
• Pathway: Colorectalcancer; Mismatch repair; Pathways in cancer
• Function: ADP binding; ATPbinding; ATPase activity; MutLalpha complex binding; centromeric DNA binding;damaged DNA binding; dinucleotide repeat insertion binding;four-way junctionDNA binding; guanine/thymine mispair binding; magnesium ion binding;nucleotide binding; oxidized purine DNA binding; protein C-terminus binding;protein homodimerization activity; single guanine insertion binding; singlethymine insertion binding; single-stranded DNA binding